Publications by authors named "Charlotte Bertheau"
Variability in CD39 and CD73 protein levels in uveal melanoma patients.
Nucleosides Nucleotides Nucleic Acids
October 2022
Extracellular adenosine is produced from ATP by CD39 and CD73, and can modulate tumor development by acting on cancer cells or immune cells. Adenosine metabolism has been poorly studied in uveal melanoma. We studied the protein levels of CD39 and CD73 in a small, well described cohort of patients with uveal melanoma.
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- - Peripheral T cell lymphomas (PTCLs) have poor clinical outcomes and are linked to chronic T cell receptor (TCR) activation, but their exact mechanisms are not well understood.
- - Research using a mouse model shows that while chronic TCR stimulation can lead to the development of PTCLs, it does not help their survival; instead, PTCLs reprogram to adopt characteristics similar to natural killer (NK) cells, expressing NK cell receptors (NKRs) and relying on specific signaling pathways.
- - Analysis of human PTCL cases indicates that a similar reprogramming occurs, prompting the need for clinical studies targeting molecules like SYK and NKRs to potentially improve treatment outcomes for this aggressive cancer.