Publications by authors named "Charlotte Bereuter"
Article Synopsis
- The 2022 International Consortium for Optic Neuritis introduced new diagnostic criteria using optical coherence tomography (OCT) to better assess optic neuritis, with a particular focus on intereye difference metrics in patients with MOG-associated optic neuritis (MOG-ON).
- A multi-center study validated the diagnostic value of pre-established intereye difference cutoff values in 66 subjects, finding that metrics from the macular ganglion cell and inner plexiform layer (mGCIP) were most sensitive and specific for diagnosing MOG-ON.
- Results indicated that OCT-based intereye difference metrics had high diagnostic accuracy for MOG-ON, especially in cases of unilateral optic neuritis, suggesting these metrics could effectively distinguish affected individuals
Article Synopsis
- The study applied the 2022 international consensus criteria for optic neuritis (ICON) to 160 patients with acute optic neuritis to assess its effectiveness in classification.
- About 50% of the patients were classified as definite optic neuritis, while 43% were not classified as having ON, mainly due to the absence of critical symptoms like relative afferent pupillary defect (RAPD) and dyschromatopsia.
- The adjusted criteria led to a higher classification of 79% of patients as having optic neuritis, highlighting the importance of thorough examinations for accurate diagnosis.*
Retinal Changes in Double-Antibody Seronegative Neuromyelitis Optica Spectrum Disorders.
Neurol Neuroimmunol Neuroinflamm
September 2024
Article Synopsis
- The study aimed to describe the clinical features of double-antibody seronegative neuromyelitis optica spectrum disorders (DN-NMOSD), focusing on how these disorders affect the retina.
- Researchers analyzed data from 25 individuals with DN-NMOSD and compared it to those with aquaporin-4 antibody positive neuromyelitis optica (AQP4-NMOSD) and healthy controls, using optical coherence tomography (OCT) to assess retinal damage.
- The findings revealed significant thinning of the retinal nerve fiber layer and ganglion cell layers in DN-NMOSD patients, even after just one optic neuritis episode, indicating severe retinal damage and neurodegeneration regardless of an ON history.
Background And Objectives: With the increasing use of visually evoked potentials (VEPs) as quantitative outcome parameters for myelin in clinical trials, an in-depth understanding of longitudinal VEP latency changes and their prognostic potential for subsequent neuronal loss will be required. In this longitudinal multicenter study, we evaluated the association and prognostic potential of VEP latency for retinal neurodegeneration, measured by optical coherence tomography (OCT), in relapsing-remitting MS (RRMS).
Methods: We included 293 eyes of 147 patients with RRMS (age [years, median ± SD] 36 ± 10, male sex 35%, F/U [years, median {IQR} 2.
Optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) regularly leads to more profound vision loss compared to multiple sclerosis (MS) and myelin-oligodendrocyte-glycoprotein-antibody associated disease (MOGAD). Here we investigate ON-related vision loss in NMOSD compared to MS and MOGAD in order to identify neuroaxonal and retinal contributors to visual dysfunction. In this retrospective study we included patients with aquaporin-4-antibody seropositive NMOSD (n = 28), MOGAD (n = 14), MS (n = 29) and controls (n = 14).
View Article and Find Full Text PDFArticle Synopsis
- Patients with AQP4-IgG+ neuromyelitis optica spectrum disorders (NMOSDs) often experience optic neuritis, leading to retinal nerve damage, but the link between this damage and primary astrocytopathy is unclear.
- This study compared retinal layer changes among 197 AQP4-IgG+ patients, 32 MOG-IgG+ patients, and 75 healthy controls using optical coherence tomography (OCT) and found no significant thinning in the outer retinal layers of AQP4-IgG+ patients.
- The research indicates that outer retinal damage may not be a consistent outcome of retinal astrocytic injury in AQP4-IgG+ NMOSD, suggesting the need
Retinal Optical Coherence Tomography in Neuromyelitis Optica.
Neurol Neuroimmunol Neuroinflamm
November 2021
Background And Objectives: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts.
Methods: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs).
Purpose: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD.
View Article and Find Full Text PDFBackground: Spinocerebellar ataxia type 1 (SCA-ATXN1) is an inherited progressive ataxia disorder characterized by an adult-onset cerebellar syndrome combined with nonataxia signs. Retinal or optic nerve affection are not systematically described.
Objectives: To describe a retinal phenotype and its functional relevance in SCA-ATXN1.
Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve and retinal damage. Evaluating retinal changes using optical coherence tomography (OCT) in diseases like multiple sclerosis has thus become increasingly relevant. However, intraretinal segmentation, a necessary step for interpreting retinal changes in the context of these diseases, is not standardized and often requires manual correction.
View Article and Find Full Text PDF