Publications by authors named "Charlotte B Campbell"
Front Immunol
November 2022
Article Synopsis
- Th9 cells produce IL-9 and differentiate from naïve T cells using signals from cytokines like IL-4, TGF-β, and IL-2, particularly in inflamed tissues.
- The study reveals that in conditions with limited IL-2, Th9 cells show lower IL-9 production and reduced NF-kB activation, indicating that IL-2 is crucial for their optimal function.
- Additionally, introducing IL-1β can enhance Th9 differentiation by activating NF-kB and suppressing the inhibitory factor BCL6, thus improving the cells' response even when IL-2 is low.
