The significance of DNA mismatch repair genes in the diagnosis and management of periocular sebaceous cell carcinoma and Muir-Torre syndrome.

Objective: The aims of this study were to determine the significance of expression of DNA mismatch repair proteins in detecting systemic malignancies in a series of patients with periocular sebaceous cell carcinoma and to determine the clinical characteristics and frequency of Muir-Torre syndrome in this cohort.

Design: The study was a retrospective non-comparative interventional case series.

Participants: 31 patients with histologically proven sebaceous cell carcinoma of the eyelid participated in the study.