Publications by authors named "Charline Nardin"
Article Synopsis
- - Merkel cell carcinoma (MCC) is often linked to the Merkel cell polyomavirus (MCPyV), particularly when the virus integrates into the host's DNA and leads to mutations in the Large T antigen (LT), which is essential for the virus's cancer-causing properties.
- - In recent cases involving MCC combined with skin tumors called trichoblastoma and poroma, researchers found evidence of MCC developing from epithelial cells and identified both mutated and wild-type LT sequences.
- - The findings indicate that some MCC cases may contain intact MCPyV genomes and express certain viral proteins, suggesting a more complex interaction between the virus and cancer than previously understood.
Although virus-negative Merkel cell carcinoma (MCC) is characterized by a high frequency of UV-induced mutations, the expression of two viral oncoproteins is regarded as a key mechanism driving Merkel cell polyomavirus‒positive MCC. The cells in which these molecular events initiate MCC oncogenesis have yet not been identified for both MCC subsets. A considerable proportion of virus-negative MCC is found in association with squamous cell carcinoma (SCC), suggesting (i) coincidental collision, (ii) one providing a niche for the other, or (iii) one evolving from the other.
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