The protective association of social cohesion on sex workers' experiences of violence and access to community support: Impacts of resource sharing, trust and connection among a community-based cohort in Metro Vancouver, Canada (2010-2022).

Objectives: To measure recent social cohesion (resource sharing, trust and support) and its association with (1) sexual/physical violence, and (2) engagement with sex work-specific services among women sex workers in Metro Vancouver, Canada.

Methods: Prospective data (January 2010-August 2022) were drawn from an open cohort of 900+ women sex workers. We developed multivariable logistic regression confounder models with generalized estimating equations (GEE) to examine associations between social cohesion and recent (1) physical/sexual violence and (2) engagement with sex work-specific services.

Gaps in health coverage for racialized im/migrant sex workers in metro Vancouver: Findings of a community-based cohort study (2014-2021).

Background: Sex workers face substantial health inequities related to sexual health and gender-based violence, many of which are amplified for the large proportion of workers who are racialized im/migrants. While criminalization and stigma are known barriers to health care for this population, we know little about health insurance coverage, and in particular how this relates to im/migration experience and racialization. We examined associations between im/migration status, duration, and racialization on gaps in health insurance coverage in a cohort of women sex workers.

Differences in Prostate Cancer Transcriptomes by Age at Diagnosis: Are Primary Tumors from Older Men Inherently Different?

Unlabelled: Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. We sought to characterize gene expression profiles of prostate tumor tissue by age at diagnosis. We conducted a discovery analysis in The Cancer Genome Atlas prostate cancer dataset (n = 320; 29% of men >65 years at diagnosis), using linear regressions of age at diagnosis and mRNA expression and adjusting for TMPRSS2:ERG fusion status and race.

European trends in cervical cancer mortality in relation to national screening programs, 1985-2014.

Background: Cervical cancer is the fourth leading oncological cause of death in women. Variable trends in cervical cancer mortality have been observed across Europe, despite the widespread adoption of screening programs. This variability has previously been attributed to heterogeneity in the quality of screening programs.

Diagnosis of Opioid Use Disorder by Youths Assessed in Acute Care Settings in British Columbia, Canada.

Objectives: To describe trends in the number of youths diagnosed with opioid use disorder (OUD) and to identify factors associated with OUD diagnosis in acute care settings.

Study Design: Data from a population-based retrospective cohort study with linkage of 6 health administrative databases for 13 009 youth age 12-24 years identified with OUD between 2001 and 2018 in British Columbia, Canada were used to describe annual diagnoses. Using a multiple logistic regression model, we estimated the association between past-year health care utilization and OUD diagnosis in acute settings, controlling for sociodemographic and OUD-related comorbid conditions.

Coffee and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study.

Reported associations between coffee consumption and an increased risk of pancreatic cancer could be due to residual confounding by smoking and/or biased recall of coffee consumption in retrospective studies. Studying associations prospectively in never smokers should minimize these problems, but thus far such studies have included relatively small numbers of cases. In our study, 309,797 never-smoking women self-reported typical daily coffee consumption at a mean age of 59.

A systematic analysis of UK cancer research funding by gender of primary investigator.

Objectives: To categorically describe cancer research funding in the UK by gender of primary investigator (PIs).

Design: Systematic analysis of all open-access data.

Methods: Data about public and philanthropic cancer research funding awarded to UK institutions between 2000 and 2013 were obtained from several sources.

Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma.

Liposarcoma is one of the most common subtypes of soft-tissue sarcoma and consists of three main subtypes, of which well-differentiated liposarcoma and dedifferentiated liposarcoma account for 40-45%. The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting. Recently, eribulin and trabectedin have been approved by the US Food and Drug Administration for recurrent liposarcomas and progress in molecular characterization of these tumors has opened up new and potential novel treatment targets.

Effects of health and social care spending constraints on mortality in England: a time trend analysis.

Objective: Since 2010, England has experienced relative constraints in public expenditure on healthcare (PEH) and social care (PES). We sought to determine whether these constraints have affected mortality rates.

Methods: We collected data on health and social care resources and finances for England from 2001 to 2014.

Unemployment and HIV mortality in the countries of the Organisation for Economic Co-operation and Development: 1981-2009.

Objectives: To determine an association between unemployment rates and human immunodeficiency virus (HIV) mortality in the Organisation for Economic Co-operation and Development (OECD).

Design: Multivariate regression analysis.

Participants: OECD member states.

Investments in cancer research awarded to UK institutions and the global burden of cancer 2000-2013: a systematic analysis.

Objectives: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs).

Design: Systematic analysis of all open-access data.

Setting And Participants: Public and philanthropic funding to all UK cancer research institutions, 2000-2013.

The impact of team familiarity and surgical experience on operative efficiency: a retrospective analysis.

Objectives: The independent impact of individual surgical experience and team familiarity on surgical performance has been widely studied; however, the interplay of these factors and their relative, quantified, contributions to performance is poorly understood. We determined the impact of team familiarity and surgeon, and cumulative team experience on operative efficiency in total knee replacement.

Design: Retrospective analysis of all total knee replacements conducted at the host institution in 1996-2009.

Unmasking the surgeons: the evidence base behind the use of facemasks in surgery.

The use of surgical facemasks is ubiquitous in surgical practice. Facemasks have long been thought to confer protection to the patient from wound infection and contamination from the operating surgeon and other members of the surgical staff. More recently, protection of the theatre staff from patient-derived blood/bodily fluid splashes has also been offered as a reason for their continued use.

Unemployment, public-sector health care expenditure and HIV mortality: An analysis of 74 countries, 1981-2009.

Background: The global economic downturn has been associated with increased unemployment and reduced public-sector expenditure on health care (PSEH). We determined the association between unemployment, PSEH and HIV mortality.

Methods: Data were obtained from the World Bank and the World Health Organisation (1981-2009).