Publications by authors named "Charlie Moffatt"
Article Synopsis
- * By using a powerful testing method, researchers identified specific sequences in mouse 3' UTRs that are essential for RNA localization to neuron extensions, which are enriched in certain nucleotides.
- * The RNA-binding protein Unk was discovered to play a crucial role in transporting these RNAs to neurites, as reducing Unk levels hindered this process.
Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism that generates diverse 3' ends on mRNA. APA patterns are often tissue specific and play an important role in cellular processes such as cell proliferation, differentiation, and response to stress. Many APA sites are found in 3' UTRs, generating mRNA isoforms with different 3' UTR contents.
View Article and Find Full Text PDF