Publications by authors named "Charlie J Clark"
Background: Copy-number variations (CNVs) have been associated with rare and debilitating genomic disorders (GDs) but their impact on health later in life in the general population remains poorly described.
Methods: Assessing four modes of CNV action, we performed genome-wide association scans (GWASs) between the copy-number of CNV-proxy probes and 60 curated ICD-10 based clinical diagnoses in 331,522 unrelated white British UK Biobank (UKBB) participants with replication in the Estonian Biobank.
Results: We identified 73 signals involving 40 diseases, all of which indicating that CNVs increased disease risk and caused earlier onset.
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy. Here we show that short peptides that promiscuously bind both chemokine classes can be identified from evasins by phage-display screening performed with multiple chemokines in parallel.
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- * The introduction of the Synthetic Biology Open Language Visual (SBOLv) allows bioengineers to visually share biological designs, but maintaining the numerous glyphs in the standard poses challenges for tool development.
- * The Python package paraSBOLv simplifies the creation of SBOLv diagrams with parametric glyph definitions, promoting faster development of biodesign tools and suggesting that adopting these definitions in the SBOLv standard could ease future tool creation and visual integration.