Differences in Prostate Cancer Transcriptomes by Age at Diagnosis: Are Primary Tumors from Older Men Inherently Different?

Unlabelled: Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. We sought to characterize gene expression profiles of prostate tumor tissue by age at diagnosis. We conducted a discovery analysis in The Cancer Genome Atlas prostate cancer dataset (n = 320; 29% of men >65 years at diagnosis), using linear regressions of age at diagnosis and mRNA expression and adjusting for TMPRSS2:ERG fusion status and race.

European trends in cervical cancer mortality in relation to national screening programs, 1985-2014.

Background: Cervical cancer is the fourth leading oncological cause of death in women. Variable trends in cervical cancer mortality have been observed across Europe, despite the widespread adoption of screening programs. This variability has previously been attributed to heterogeneity in the quality of screening programs.

Coffee and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study.

Reported associations between coffee consumption and an increased risk of pancreatic cancer could be due to residual confounding by smoking and/or biased recall of coffee consumption in retrospective studies. Studying associations prospectively in never smokers should minimize these problems, but thus far such studies have included relatively small numbers of cases. In our study, 309,797 never-smoking women self-reported typical daily coffee consumption at a mean age of 59.

A systematic analysis of UK cancer research funding by gender of primary investigator.

Objectives: To categorically describe cancer research funding in the UK by gender of primary investigator (PIs).

Design: Systematic analysis of all open-access data.

Methods: Data about public and philanthropic cancer research funding awarded to UK institutions between 2000 and 2013 were obtained from several sources.

Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma.

Liposarcoma is one of the most common subtypes of soft-tissue sarcoma and consists of three main subtypes, of which well-differentiated liposarcoma and dedifferentiated liposarcoma account for 40-45%. The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting. Recently, eribulin and trabectedin have been approved by the US Food and Drug Administration for recurrent liposarcomas and progress in molecular characterization of these tumors has opened up new and potential novel treatment targets.

Investments in cancer research awarded to UK institutions and the global burden of cancer 2000-2013: a systematic analysis.

Objectives: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs).

Design: Systematic analysis of all open-access data.

Setting And Participants: Public and philanthropic funding to all UK cancer research institutions, 2000-2013.

The impact of team familiarity and surgical experience on operative efficiency: a retrospective analysis.

Objectives: The independent impact of individual surgical experience and team familiarity on surgical performance has been widely studied; however, the interplay of these factors and their relative, quantified, contributions to performance is poorly understood. We determined the impact of team familiarity and surgeon, and cumulative team experience on operative efficiency in total knee replacement.

Design: Retrospective analysis of all total knee replacements conducted at the host institution in 1996-2009.