Publications by authors named "Charlie C Mundorff"
Rapid Assessment of Pepsin Column Activity for Reliable HDX-MS Studies.
J Am Soc Mass Spectrom
September 2021
Article Synopsis
- * The standard method involves using pepsin for protein digestion but can lead to variability due to the extent of proteolytic cleavage.
- * A new peptide-based assay is introduced to easily evaluate pepsin activity without needing system changes, offering quick feedback for benchmarking across various HDX-MS setups.
Age-related lens cataract is the major cause of blindness worldwide. The mechanisms whereby crystallins, the predominant lens proteins, assemble into large aggregates that scatter light within the lens, and cause cataract, are poorly understood. Due to the lack of protein turnover in the lens, crystallins are long-lived.
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