Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience.

Background: The emergence and attendant mortality of vaccine-induced immune thrombocytopenia and thrombosis (VITT) as a consequence of vaccination against severe acute respiratory syndrome coronavirus 2 have resulted in some patients with VITT being considered as deceased organ donors. Outcomes after kidney transplantation in this context are poorly described. Because the disease seems to be mediated by antiplatelet factor 4 antibodies, there is a theoretical risk of transmission via passenger leukocytes within the allograft.

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology.

Autism spectrum disorder (ASD) is a challenging neurodevelopmental disorder with symptoms in social, language, sensory, motor, cognitive, emotional, repetitive behavior, and self-sufficient living domains. The important research question examined is the elucidation of the pathogenic neurocircuitry that underlies ASD symptomatology in all its richness and heterogeneity. The presented model builds on earlier social brain research, and hypothesizes that four social brain regions largely drive ASD symptomatology: amygdala, orbitofrontal cortex (OFC), temporoparietal cortex (TPC), and insula.

Exaggerated blood pressure response to dynamic exercise despite chronic refractory hypotension: results of a human case study.

Background: Chronic refractory hypotension is a rare but significant mortality risk in renal failure patients. Such aberrant physiology usually deems patient unfit for renal transplant surgery. Exercise stimulates the mechano-chemoreceptors in the skeletal muscle thereby modulating the sympathetic effects on blood pressure regulation.

Posttraumatic stress disorder: a theoretical model of the hyperarousal subtype.

Posttraumatic stress disorder (PTSD) is a frequent and distressing mental disorder, about which much remains to be learned. It is a heterogeneous disorder; the hyperarousal subtype (about 70% of occurrences and simply termed PTSD in this paper) is the topic of this article, but the dissociative subtype (about 30% of occurrences and likely involving quite different brain mechanisms) is outside its scope. A theoretical model is presented that integrates neuroscience data on diverse brain regions known to be involved in PTSD, and extensive psychiatric findings on the disorder.

An unusual presentation of atrial myxoma with haematuria and proteinuria.

Myxomas are uncommon primary cardiac tumours, usually affecting the left atrium. We describe an unusual presentation of cardiac myxoma with asymptomatic proteinuria and haematuria. Surgical excision of the tumour resulted in complete resolution of the urinary abnormalities.

Comparison of preparation design and material thickness on microbial leakage through Cavit using a tooth model system.

Few studies have compared Cavit thickness and access design as factors in microbial leakage. The present study used an acrylic tooth model to measure leakage of Streptococcus mutans. Pilot studies confirming the sterility of Cavit showed it will inhibit microbial growth for 2 days.

Effects of time and concentration of sodium ascorbate on reversal of NaOCl-induced reduction in bond strengths.

The use of NaOCl as an endodontic irrigant lowers the bond strength of resin cements but this can be reversed by the use of 10% sodium ascorbate for 10 min. The objective of this study was to evaluate the effect of time and concentration of ascorbate at restoring the bond strength. Group 1 roots were prepared using 0.

Effects of EGF and IGF-1 on proliferation of cultured human proximal tubule cells after oxidant stress.

Background: Both insulin-like growth factor-1 (IGF-1) and epidermal growth factor (EGF) stimulate proliferation of various renal tubule epithelial cells in culture including proximal tubule cells. In some epithelial cells, the effects of EGF and IGF-1 are additive or synergistic. The effects of EGF and IGF-1 in cultured tubule epithelial cells following injury are limited.