[ Ga]Ga-PentixaFor: Development of a fully automated in hospital production on the Trasis miniAllinOne synthesizer.

[ Ga]Ga-PentixaFor is a frequently used radiotracer to image the CXCR4/CXCL12 axis in various malignancies, infections, and cardiovascular diseases. To answer increasing clinical needs, an automatized synthesis process ensuring efficient and reproducible production and improving operator's radioprotection is needed. [ Ga]Ga-PentixaFor synthesis has been described on other synthesizers but not on the miniAiO.

Correction: Pacelli et al. Fully Automated, High-Dose Radiosynthesis of [18F]PARPi. 2022, , 865.

Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont and Alex Jackson were not included as authors in the original publication [...

multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated F-fluorination.

Background: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABARs). Positron Emission Tomography (PET) imaging of the GABAARs with [C]FMZ has been used to evidence alterations in neuronal density, to assess target engagement of novel pharmacological agents, and to study disorders such as epilepsy and Huntington's disease. Despite the potential of FMZ PET imaging the short half-life (t) of carbon-11 (20 min) has limited the more widespread clinical use of [C]FMZ.

Fully Automated Ga-Labeling and Purification of Macroaggregated Albumin Particles for Lung Perfusion PET Imaging.

Lung PET/CT is a promising imaging modality for regional lung function assessment. Our aim was to develop and validate a fast, simple, and fully automated GMP compliant [Ga]Ga-MAA labeling procedure, using a commercially available [Tc]Tc-MAA kit, a direct gallium-68 eluate and including a purification of the [Ga]Ga-MAA. The synthesis parameters (pH, heating temperature) were manually determined.

Automated synthesis of Ga/ Lu-PSMA on the Trasis miniAllinOne.

Prostate-specific membrane antigen (PSMA)-based radioligands for positron emission tomography (PET)/computed tomography (CT) studies represent the gold standard for detection of recurrent prostate cancer (PCa). [ Ga]PSMA-HBED-CC is a PET radiotracer suitable for detection of PCa, and its clinical use has become widespread over the last few years. In this contribution, we detail our GMP-compliant production of [ Ga]PSMA-HBED-CC using the Trasis miniAllinOne radiosynthesizer and report synthetic and clinical data for the first 100 productions of 2019.

A covalently anchored homogeneous gold complex on carbon nanotubes: a reusable catalyst.

The gold complex [Tf2NAuPPh3CH2NH2] was synthesized and covalently anchored on modified carbon nanotubes in order to obtain a supported gold homogeneous catalyst. Simple 1,6 enynes were chosen as benchmark substrates to assess its behaviour in cyclization catalysis as well as study its recycling.

Catalysis with Gold Complexes Immobilised on Carbon Nanotubes by π-π Stacking Interactions: Heterogeneous Catalysis versus the Boomerang Effect.

A new pyrene-tagged gold(I) complex has been synthesised and tested as a homogeneous catalyst. First, a simple 1,6-enyne was chosen as a model substrate for cyclisation by using different solvents to optimise the reaction conditions. The non-covalent immobilisation of our pyrene-tagged gold complex onto multi-walled carbon nanotubes through π-π stacking interactions was then explored to obtain a supported homogeneous catalyst.

Radical addition of xanthates on carbon nanotubes as an efficient covalent functionalization method.

Radical-initiated support: Xanthates were used as chemical reagents for the sidewall covalent functionalization of carbon nanotubes (see figure). The best grafting yields were obtained with stoichiometric ratios of xanthate and the radical initiator lauroyl peroxide. One grafted function was used as a tether for bimetallic cluster compounds, which were converted into very small (1-2 nm) supported nanoparticles upon heating.