Publications by authors named "Charles Vaughn Sindelar"
Article Synopsis
- Spirochete bacteria swim using a unique method that involves undulating movements powered by supercoiled 'endoflagella' that wrap around their bodies.
- Researchers studied the structure of these flagellar filaments using advanced techniques like cryo-electron tomography and X-ray crystallography.
- Their findings revealed that the filaments are covered by a complex, asymmetric sheath layer, which differs from the simpler structures seen in other bacteria, helping to explain the special supercoiling necessary for the spirochete's motility.
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in microtubule sliding.
View Article and Find Full Text PDFPreviously, we showed that synaptotagmin1 (Syt1) forms Ca-sensitive ring-like oligomers on membranes containing acidic lipids and proposed a potential role in regulating neurotransmitter release (Zanetti et al., 2016). Here, we report that Syt1 assembles into similar ring-like oligomers in solution when triggered by naturally occurring polyphosphates (PIP2 and ATP) and magnesium ions (Mg).
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