Evaluation of a rapid DNA process with the RapidHIT ID system using a specialized cartridge for extracted and quantified human DNA.

The turn-around time of urgent crime scene DNA samples is often far longer than desired by law enforcement. Crime scene DNA sample processing involves both complex and routine processing steps. Simplification and integration of the routine steps would dramatically improve turn-around time and reduce the risk of operator contamination.

Validation of a rapid DNA process with the RapidHIT ID system using GlobalFiler Express chemistry, a platform optimized for decentralized testing environments.

The RapidHIT ID is a fully automated sample-to-answer system for short tandem repeat (STR)-based human identification. The RapidHIT ID has been optimized for use in decentralized environments and processes presumed single source DNA samples, generating Combined DNA Index System (CODIS)-compatible DNA profiles in less than 90min. The system is easy to use, requiring less than one minute of hands-on time.

Developmental validation of a fully integrated sample-to-profile rapid human identification system for processing single-source reference buccal samples.

Unlabelled: Short tandem repeat (STR) DNA typing is a global standard for human identification. Current practice involves highly trained forensic analysts, operating in a laboratory setting, using multiple instruments to process samples and analyze the data. Here, we report the developmental validation of a fully integrated and automated DNA profiling system, the RapidHIT® System, capable of producing up to five high quality STR profiles with full controls in approximately 90min using PowerPlex®16 HS RapidHIT chemistry.

Design and implementation of microarray gene expression markup language (MAGE-ML).

Background: Meaningful exchange of microarray data is currently difficult because it is rare that published data provide sufficient information depth or are even in the same format from one publication to another. Only when data can be easily exchanged will the entire biological community be able to derive the full benefit from such microarray studies.

Results: To this end we have developed three key ingredients towards standardizing the storage and exchange of microarray data.