Publications by authors named "Charles Siegert"

Background: The optimal treatment of stage I non-small-cell lung carcinoma is subject to debate. The aim of this study was to compare overall survival and oncologic outcomes of lobar resection (LR), sublobar resection (SR), and stereotactic body radiotherapy (SBRT).

Methods: A systematic review and meta-analysis of oncologic outcomes of propensity matched comparative and noncomparative cohort studies was performed.

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Article Synopsis
  • Early-stage non-small-cell lung cancer (NSCLC) treatment is debated; lobar resection is standard, but sublobar resections, which preserve lung tissue, show promising results.
  • A systematic review and meta-analysis compared outcomes between lobar resections and parenchymal-sparing techniques for T1a NSCLC, analyzing data from 28 studies.
  • Findings indicate no significant difference in 5-year overall survival rates between the two surgical approaches, although parenchymal-sparing surgery may present risks related to nodal upstaging in patients who could tolerate lobectomy.
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Article Synopsis
  • SBRT is a potentially curative treatment for early-stage NSCLC, but its survival outcomes might vary based on whether the diagnosis is clinically or biopsy-proven.
  • The systematic review analyzed 43 studies, revealing that patients with biopsy-proven disease had lower 3-year overall survival and cancer-specific survival rates compared to those diagnosed clinically, although 5-year overall survival rates were similar for both groups.
  • The findings underline the significance of obtaining pathological confirmation of malignancy before treating with SBRT, as this could impact patient outcomes.
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Purpose Of Review: Obesity has been recognized as an impactful comorbid condition. It has been demonstrated to be an independent risk factor for morbidity and mortality following trauma.

Recent Findings: Multiple studies and reviews have strongly suggested obesity to be associated with increased risk for post-injury morbidity and mortality.

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Background: Phone triaging patients with suspected malignant pleural mesothelioma (MPM) within the Veterans Healthcare Administration (VHA) system offers a model for rapid, expert guided evaluation for patients with rare and treatable diseases within a national integrated healthcare system. To assess feasibility of national open access telephone triage using evidence-based treatment recommendations for patients with MPM, measure timelines of the triage and referral process and record the impact on "intent to treat" for patients using our service.

Methods: A retrospective study.

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Background: Benign metastasizing leiomyomas (BMLs) represent the extrauterine spread of a benign uterine process. Pulmonary BMLs are the most common example of distant spread of uterine leiomyomas and are usually found incidentally in premenopausal women. The rarity of BMLs accounts for the limited literature that currently exists regarding their underlying pathophysiology, disease course, and management.

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Background: Trauma is the leading cause of death from ages 1-44-y in the United States and the fifth leading cause of death overall, but there are few studies quantifying trauma education in medical school. This study reviews curriculum hours devoted to trauma education at a northeastern medical school.

Materials And Methods: We reviewed the preclinical curriculum at a northeastern medical school affiliated with three adult and two pediatric level I trauma centers verified by the American College of Surgeons.

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