Ocular Features and Autism Spectrum Disorder: A 10-Year Retrospective Review.

We reviewed the medical records of our pediatric ophthalmology and strabismus clinic of our hospitals for the period 1 January, 2009 to 31 December, 2018, to identify children with autism spectrum disorder (ASD). We found that refractive errors (62%) and strabismus (63%) were the most common ocular manifestations in children with ASD. With timely management, amblyopia and strabismus could have favorable outcome.

Combined Phacoendoscopic Cyclophotocoagulation versus Combined Phacotrabeculectomy in the Management of Coexisting Cataract and Glaucoma: A Comparative Study.

Purpose: To compare the surgical outcome of combined phacoemulsification and endoscopic cyclophotocoagulation (phacoECP) versus combined phacoemulsification and mitomycin C-augmented trabeculectomy (phacoTbx) in patients with coexisting glaucoma and visually significant cataract.

Methods: A retrospective review of 89 eyes of 89 patients who received phacoECP (=49) and phacoTbx (=40) was carried out at a tertiary eye center in Hong Kong. The minimum follow-up period was 6 months.

Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma.

Background/aims: Loss of heterozygosity (LOH) has been discovered in retinoblastoma (RB) in previous studies. In this study, we aimed to discover potential tumour suppressor genes through investigation of the incidence of allelic loss in chromosome 1, 6, 9, 13, 19, 20, 21, 22 and X in Chinese sporadic retinoblastoma patients and to study the expression of genes flanking LOH region 13q31.

Methods: Twenty-five microdissected RB samples were analysed to investigate the LOH in 140 microsatellite markers.

Prenatal screening for retinoblastoma in Hong Kong.

We report the first use in Hong Kong of molecular techniques to screen prenatally for retinoblastoma and review 17 cases of retinoblastoma seen at the Hong Kong Eye Hospital from 2001 to 2006. A pregnant couple whose first child had retinoblastoma requested prenatal screening for retinoblastoma during their second pregnancy in 2000. Whole RB1 coding gene sequencing was performed on peripheral blood cells taken from family members and cultured amniocytes collected from the foetus during the 14th week of gestation.

Multiple gene polymorphisms in the complement factor h gene are associated with exudative age-related macular degeneration in chinese.

Purpose: Variants in the complement factor H (CFH) gene have been shown to be strongly associated with age-related macular degeneration (AMD). In this study, sequence alterations in CFH were investigated in 163 Chinese patients with exudative AMD and 155 unrelated Chinese control subjects.

Methods: All the 22 CFH exons, intron-exon boundaries, and promoter sequences were screened by polymerase chain reaction and DNA sequencing.

Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy.

Purpose: To evaluate the relationships between optic disc measurements, obtained by an optical coherence tomograph and a confocal scanning laser ophthalmoscope, and myopia.

Methods: One hundred thirty-three eyes from 133 healthy subjects with mean spherical equivalent -6.0 +/- 4.