Publications by authors named "Charles R Beamon"
Objective: To investigate if sildenafil citrate can inhibit the functional and structural changes of the detrusor in a murine model of bladder outlet obstruction (BOO). Phosphodiesterase type 5 (PDE-5) inhibitors have recently been used for treating urinary symptoms associated with prostatic obstruction, but it is unclear whether PDE-5 inhibition acts on the prostatic urethra or the bladder.
Materials And Methods: In 18 male Balb/CAN mice, partial BOO was created and the mice allowed to survive for 6 weeks.