The project studied the effects of two omega-3 fatty acids, EPA and DHA, on reducing heart tissue damage (infarct size) in rats after a simulated heart attack.
Rats were fed different diets for 14 days, then subjected to a procedure simulating heart ischemia and reperfusion, with various measurements taken afterward.
Results showed that both EPA and DHA reduced infarct size on their own, increased Akt protein activity, and provided specific protective effects against cell death and mitochondrial damage, but their combined effect did not enhance the benefits.