Publications by authors named "Charles P Moore"
Article Synopsis
- - The study investigates how a soft spherical particle gets trapped in a rectangular slit, leading to a complex relationship between pressure and flow rate at low Reynolds numbers.
- - Simulations show that the particle's deformation alters the flow, concentrating streamlines in a small area and significantly raising the resistance to flow as pressure increases.
- - Two distinct flow regimes are identified: a "flow-dominated" regime with small deformations where flow rate rises with pressure, and an "elastic-dominated" regime where larger deformations obstruct the flow.
Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery.
Expert Opin Drug Deliv
December 2018
Introduction: Aerosol drug delivery to the lungs via inhalation is widely used in the treatment of respiratory diseases. The deposition pattern of inhaled particles within the airways of the respiratory tract is key in determining the initial delivered dose. Thereafter, dose-dependent processes including drug release or dissolution, clearance, and absorption influence local and systemic exposure to inhaled drugs over time.
View Article and Find Full Text PDFBackground: Primary benefits of high flow nasal cannula therapy include washout of carbon dioxide rich exhaled gas and increased airway pressures during tidal breathing. This work reports on the influence of high flow nasal cannula outlet area on upper airways gas clearance and tracheal pressures using measurements in five realistic adult nose-throat airway replicas.
Methods: Two commercial high flow nasal cannulas and one generic nasal cannula of varying size were compared.