Physical field-assisted deep eutectic solvent processing: A green and water-saving extraction and separation technology.

Extraction of organic and bioactive compounds from plant materials with the traditional organic solvents aided by water or oil bath heating is not sustainable, because it consumes a lot of energy, time, water/oil, solvents, and results in lower yield. This review discusses deep eutectic solvent (DES) as a green solvent, physical field technology (PFT) as a water-saving and green technology, and how the coupling of PFT (ultrasound [US], microwave [MW], infrared [IR]) to DES will improve the yield and quality of protein, polysaccharides, polyphenols, pectin, and terpenoids extracted from plant materials. Ultrasonication increases DES extraction efficiency via cavitation dislodgement and pores creation.

Beta vulgaris L. beetroot protects against iron-induced liver injury by restoring antioxidant pathways and regulating cellular functions.

Beta vulgaris L. is a root vegetable that is consumed mainly as a food additive. This study aimed to describe the protective effect of B.

Changes in flavor profile of vegetable seasonings by innovative drying technologies: A review.

Seasonings like garlic, ginger, and scallion provide spicy and masking flavor or aroma in vegetables. However, the method or technique used for drying these spices can affect the flavor profile. Therefore, this review focuses on vegetable seasonings like ginger, garlic, and scallion, the characteristic flavor of fresh and dehydrated vegetable seasoning, and how drying methods (freeze-drying [FD], convective hot air drying [HAD], infrared drying, microwave drying [MW]), and other recent dryers (swirling fluidized bed [SFB], pulsed-vacuum dryer, relative humidity-convective dryer, etc.

A review on rebaudioside M: The next generation steviol glycoside and noncaloric sweetener.

So far, the use of artificial low-calorie sweeteners, like sucralose, saccharin, and so on, to replace the conventional-based sugars has not succeeded due to the long-term adverse health effects, for example, hypertension, and not well-known safety stand. In this review, we discussed the next generation SvGl (rebaudioside M [Reb M]), their biosynthetic pathway in plant, high-yield production via microbial fermentation and enzyme engineering, physicochemical properties, taste modification, kinetic metabolism, application in food and beverages, safety and toxicological evaluation, regulation and dosage recommendation, and health benefits. In stevia, the biosynthesis of stevia glycosides, especially Reb M, is derived from the bifurcation of the pathway leading to gibberellin, followed by subsequent enzymatic modification of rubusoside.

Evaluation of Antimalarial Activity of Ethanolic Extract of .: An and an Approach.

In Nigeria, L. has been used to treat a variety of ailments. The mechanism of the antimalarial activity of ethanolic leaf extract of (EEAML) was investigated using both an in vivo and an in silico approach.

modeling revealed phytomolecules derived from (DC.) leaf extract as promising candidates for malaria therapy.

The emergence of varying levels of resistance to currently available antimalarial drugs significantly threatens global health. This factor heightens the urgency to explore bioactive compounds from natural products with a view to discovering and developing newer antimalarial drugs with novel mode of actions. Therefore, we evaluated the inhibitory effects of sixteen phytocompounds from leaf extract against drug targets such as circumsporozoite protein (PfCSP), merozoite surface protein 1 (PfMSP1) and erythrocyte membrane protein 1 (PfEMP1).

Molecular docking and experimental validation of the effect of ergothioneine on heat shock protein-70 following endurance exercise by Arabian stallions.

Background: Exercise-induced oxidative stress is a challenge in equine sports. This study aims at determining the effects of ergothioneine on heat shock protein-70 (HSP-70) following the stress of an endurance exercise of 30 km by Arabian stallions. Molecular docking was also done to investigate the interaction between the ligand ergothioneine and heat shock protein-70 using sulfogalactosylceramide and sulfogalactoglycerolipid as standards.

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats.

Background: Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats.

In Vivo Antiplasmodial Potential of the Leaf, Mesocarp, and Epicarp of the Plant in Mice Infected with NK65.

Results: The presence of alkaloids, fats and oils, phenolic, and flavonoids was detected via the qualitative test which was confirmed from the result obtained from the GC-MS chromatogram of ethanolic leaves extract. The GC-MS chromatogram of the constituents analogous to the twenty peaks was analyzed as follows: dodecanoic acid (1.94%), 2-undecanone (3.

Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Exhibits Antioxidant Mechanism for Abrogation of Cyclophosphamide-Induced Cardiac Damage and Oxidative Hepatorenal Toxicity in Rats.

Cyclophosphamide (CYP) is a potent DNA-interactive anticancer drug; however, its clinical drawbacks are chiefly associated with induction of oxidative multi-organ toxicity. Sitagliptin (STG) is an antidiabetic dipeptidyl peptidase-4 inhibitor drug with antioxidant efficacy. Herein, we have explored whether STG could abrogate the CYP-induced oxidative stress-mediated cardiac and hepatorenal toxicities in male rats.

Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats.

The management of diabetes over the years has involved the use of herbal plants, which are now attracting interest. We assessed the antidiabetic properties of aqueous extract of shoots (AECPS) and the mechanism of action on pancreatic -cell dysfunction. This study was conducted using Thirty-six 36) male Wistar rats.

Comparative effects of combined use of alcohol with cannabis and tobacco on testicular function in rats.

Alcoholism has been linked to problems with male reproductive function. The combined effects of alcohol, cannabis, and tobacco were compared in this study. A total of 35 rats were assigned randomly into seven groups A-G: animals in A were administered distilled water.

Exploring the potentials of some compounds from Garcinia kola seeds towards identification of novel PDE-5 inhibitors in erectile dysfunction therapy.

Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and is characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in the pharmacies, though normally associated with several adverse. This study was designed to assess the molecular relations obtainable between catechin, garcinal, garcinoic acid and d-tocotrienol compounds isolated from Garcinia kola and targeted receptor linked to ED.

Deciphering the Interactions of Bioactive Compounds in Selected Traditional Medicinal Plants against Alzheimer's Diseases via Pharmacophore Modeling, Auto-QSAR, and Molecular Docking Approaches.

Neurodegenerative diseases, for example Alzheimer's, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, for example flavonoids, are documented in studies for having the ability to pass the blood-brain barrier and moderate the development of such illnesses. Computer-aided drug design (CADD) has achieved importance in the drug discovery world; innovative developments in the aspects of structure identification and characterization, bio-computational science, and molecular biology have added to the preparation of new medications towards these ailments.

Production of a Complementary Food: Influence of Cowpea Soaking Time on the Nutritional, Antinutritional, and Antioxidant Properties of the Cassava-Cowpea-Orange-Fleshed Potato Blends.

Soaking and incorporation of legumes for fortification are essential to a complementary food production process. Cassava, orange-fleshed potato, and cowpeas are sustainably cheap, locally available, and underutilized for food biofortification. This study investigated the effect of cowpea soaking time (3, 6, and 9 h) on different composition ratios of cassava, cowpea, and orange-fleshed sweet potato (CCP) blends (50 : 40 : 10 (EC), 50 : 30 : 20 (FC), 50 : 20 : 30 (GC), and 50 : 50 : 0 (HC)).

Exopolysaccharides from bacteria and fungi: current status and perspectives in Africa.

Bacterial and fungal exopolysaccharides (EPSs) are extracellular metabolites of living organisms (plants, animals, algae, bacteria and fungi) associated with adaptation, survival and functionalities. The EPSs also afford humans multiple value-adding applications across different spheres of endeavors. The variable chemical and biochemical architecture that characterizes an EPS presets its biological functionality and potential biotechnological benefits.

Biochemical evaluation and molecular docking assessment of the anti-inflammatory potential of leaf against ulcerative colitis.

Ulcerative colitis (UC) is an inflammation of the colon that can progress to colorectal cancer if left untreated. No medication completely cures UC and natural products are sources of alternative approaches. This study aimed to determine the anti-inflammatory potential of leaf extract and fractions in a rat model of ulcerative colitis and to identify the active ingredients.

Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure-activity relationship.

Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii. Limitations of available treatments motivate the search for better therapies for toxoplasmosis. In this study, we synthesized a series of new imidazole derivatives: bis-imidazoles (compounds 1-8), phenyl-substituted 1H-imidazoles (compounds 9-19), and thiopene-imidazoles (compounds 20-26).

Screening to Identify Anti- Compounds and Modeling for Bioactivities and Toxicity.

Toxoplasmosis, which affects more than a billion people worldwide, is a common parasitic infection caused by the obligate intracellular parasite, . Current treatment strategies have several limitations, including unwanted side effects and poor efficacy. Therefore, newer therapies are needed for toxoplasmosis.

Metal nanoparticles restrict the growth of protozoan parasites.

The Trypanosoma and Toxoplasma spp, are etiological agents of diseases capable of causing significant morbidity, mortality and economic burden, predominantly in developing countries. Currently, there are no effective vaccines for the diseases caused by these parasites; therefore, therapy relies heavily on antiprotozoal drugs. However, the treatment options for these parasitic diseases are limited, thus underscoring the need for new anti-protozoal agents.