TB diagnostic insights, progress made on point of care diagnostics and bioinformatics as an additional tool for improvement.

Despite major efforts made to control tuberculosis disease (TB), this disease continues to present a major global health challenge and drug resistance is continuously growing. TB is caused by Mycobacterium tuberculosis and spreads exclusively via human-to-human contact transmission. Therefore, early detection and diagnosis for proper treatment with active TB have a great impact on public health.

Laser-enabled delivery of antiretroviral drugs into HIV-1 infected TZM-bl cells.

The use of femtosecond laser to create sub-microscopic transient pores on the cell membrane allowing exogenous material into mammalian cells has become a very efficient optical delivery method over the past decade. This study focuses on laser-enabled delivery of antiretroviral (ARV) drugs into HIV-1 infected TZM-bl cells in vitro. A 1 kHz femtosecond laser emitting at a wavelength of 800 nm was used to photoporate cells at 6.