Publications by authors named "Charles M Harper"

New technologies in medicine, even if they are promising medically, are often expensive and logistically difficult to implement at the hospital level. Transcatheter aortic valve replacement (TAVR) is a model technology that is revolutionary in treating aortic stenosis, but has been plagued with significant challenges with financial sustainability. In this article, a margin analysis at the hospital level was performed using literature data.

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Transcatheter aortic valve replacement is a relatively recent revolutionary treatment that has now become a standard procedure for treating severe aortic stenosis. In this article, the authors review the clinical history of transcatheter aortic valve replacement, summarize the major clinical trials, and describe the evolution of the technique over time. In doing so, the authors hope to provide a clear and concise review of the history and clinical evidence behind transcatheter aortic valve replacement.

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Online physician reviews have become increasingly prevalent and are a common means by which patients explore medical options online. Currently, there are no data comparing physicians with negative online reviews and those without negative reviews. We sought to compare industry-vetted patient satisfaction surveys (PSSs), such as Press Ganey (PG) PSSs, between those physicians with negative online reviews and those without negative reviews.

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Introduction: The pace of medical discovery is accelerating to the point where caregivers can no longer keep up with the latest diagnosis or treatment recommendations. At the same time, sophisticated and complex electronic medical records and clinical systems are generating increasing volumes of patient data, making it difficult to find the important information required for patient care. To address these challenges, Mayo Clinic established a knowledge management program to curate, store, and disseminate clinical knowledge.

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Article Synopsis
  • Immune therapies like IVIG and PLEX are primary treatments for worsening myasthenia gravis, with PLEX preferred during myasthenic crises and IVIG gaining popularity due to cost and convenience.
  • A review was conducted involving a randomized trial comparing IVIG and PLEX in 84 patients, measuring functional outcomes through the Quantitative Myasthenia Gravis Score at 14 days post-treatment.
  • Results indicated no significant difference in effectiveness between IVIG and PLEX, suggesting treatment choices may depend on factors like respiratory issues, other health conditions, medication access, and cost, with PLEX still preferred in severe cases.
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Article Synopsis
  • Pediatric-onset stiff-man syndrome (SMS) is a rare but potentially underdiagnosed condition in children's neurology, with this study focusing on patients diagnosed before age 18.
  • A review of records from the Mayo Clinic found 8 childhood-onset SMS cases, representing 5% of SMS patients studied, with symptoms first appearing around age 11.
  • Many of these patients faced misdiagnosis and had coexisting autoimmune disorders, with notable improvements seen from symptomatic therapies like diazepam.
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The business case for health-care quality improvement is presented. We contend that investment in process improvement is aligned with patients' interests, the organization's reputation, and the engagement of their workforce. Four groups benefit directly from quality improvement: patients, providers, insurers, and employers.

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Introduction: Accuracy of needle electromyography is typically ensured by use of anatomical landmarks and auditory feedback related to voluntary activation of the targeted muscle; however, in certain clinical situations, landmarks may not be palpable, auditory feedback may be limited or not present, and targeting a specific muscle may be more critical. In such settings, image guidance might significantly enhance accuracy.

Methods: Two electromyographers with different levels of experience examined 14 muscles in each of 4 fresh-frozen cadaver lower limbs.

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We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper deficiency. Prompt and complete reversal of the hematologic abnormalities occurred with copper replacement.

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