Publications by authors named "Charles Le Cicle"
Article Synopsis
- The pituitary gland plays a key role in regulating body functions through hormones, with gonadotrope cells being crucial for reproductive health.
- This review explores recent research on gonadotrope differentiation, focusing on the progenitor cells that develop into gonadotropes, the initiation of Nr5a1 expression, and the formation of gonadotrope networks.
- It highlights advancements in our understanding of gonadotrope development, including new insights into its developmental pathway, regulatory mechanisms involving ERα, and the molecular processes necessary for network formation during embryogenesis.
Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis, colonize the pituitary glands and organize in tridimensional networks, which are believed to be crucial to ensure proper regulation of fertility. However, the molecular mechanisms regulating the organization of gonadotrope cell population during embryogenesis remain poorly understood.
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