Publications by authors named "Charles K Moore"
Article Synopsis
- The study investigates the genetic factors associated with advanced dilated cardiomyopathy (DCM), particularly focusing on rare genetic variants related to patients requiring devices like left ventricular assist devices (LVAD) or heart transplants (HT).
- Researchers analyzed data from a diverse group of 1,198 patients enrolled in a precision medicine study, classifying the severity of DCM based on treatment type and assessing genetic variants in 36 related genes.
- Findings revealed that 26.2% of patients with advanced DCM (LVAD/HT) had pathogenic genetic variants, significantly more than those with only an implantable cardioverter defibrillator (15.9%) or neither treatment (15.0%), indicating a strong genetic link to
Article Synopsis
- - The study investigates the genetic differences in dilated cardiomyopathy (DCM) among Black, Hispanic, and White patients, noting that Black patients face higher familial risk and worse health outcomes compared to White patients, despite most existing genetic data coming from the latter group.
- - Researchers conducted a cross-sectional study involving over 1,000 patients across various US heart failure centers, focusing on genetic variants in 36 DCM-related genes, classified based on their significance and clinical impact.
- - Findings revealed that Black patients displayed a lower percentage of clinically actionable genetic variants compared to White patients (8.2% vs 25.5%), particularly in the TTN gene, highlighting potential disparities in genetic influences on DCM severity among different ances
Article Synopsis
- Cardiovascular screening for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM) was studied to determine its effectiveness among those without known familial DCM and across different demographics.
- The study involved 1,365 adult FDRs who underwent echocardiograms and ECGs, revealing that 14.1% were newly diagnosed with DCM, left ventricular systolic dysfunction (LVSD), or left ventricular enlargement (LVE).
- The results showed higher diagnosis rates in older FDRs and those with hypertension or obesity, indicating that screening is beneficial for all FDRs, regardless of race or ethnicity.
Article Synopsis
- The DCM Precision Medicine Study aimed to improve the communication of genetic disease risk among first-degree relatives of individuals diagnosed with dilated cardiomyopathy (DCM), focusing on enhancing participation in clinical screenings.
- A booklet was created to assist probands in conveying the importance of cardiovascular screening to their at-risk family members, and its effectiveness was evaluated in a large controlled trial.
- Results showed that first-degree relatives of probands who received the booklet had a higher screening completion rate (19.5%) compared to those who did not receive it (16.0%), indicating the booklet's success in motivating screenings.
Article Synopsis
- Early detection of idiopathic dilated cardiomyopathy (DCM) in at-risk family members can allow for earlier treatment, but most research has focused on White patients, ignoring the higher risks faced by Black patients.* -
- This study aimed to assess how common familial DCM is among patients with the condition and to determine the risk for first-degree relatives across different racial and ethnic groups.* -
- The research involved 1,220 DCM patients and their family members, finding a 11.6% prevalence of familial DCM in those studied, which could rise to 29.7% if all relatives were screened.*
A patient with severe mitral regurgitation and chronic systolic heart failure taking inotropic support at home presents for transcatheter edge-to-edge mitral valve repair, complicated by torrential mitral regurgitation from damaged mitral leaflets requiring escalating mechanical circulatory support and ultimately expedited orthotopic heart transplantation. ().
View Article and Find Full Text PDFHeart failure (HF) has emerged as a global epidemic and it affects about 6 million adults in the US. HF medical treatment, as recommended in guidelines, significantly improves survival and quality of life; however, the mortality burden of HF remains high. For decades, treatment has been guided, mainly by symptoms, leading to undertreatment in a range of settings.
View Article and Find Full Text PDFIn cardiac transplantation settings, the initial myocardial ischemia and reperfusion may cause myocyte tissue injury and the release of allograft inflammatory factor-1 (AIF-1). This in part may trigger the innate immune response through the modulation of Toll-like receptor-2 (TLR-2) and AIF-1 expression and function, causing the release of proinflammatory cytokines. The goal was to demonstrate these markers in the peripheral blood and biopsy specimen from recipients with cardiac allograft rejection and coronary vasculopathy (CV).
View Article and Find Full Text PDFFrequency distribution of cytochrome P450 3A4 gene polymorphism in ethnic populations and in transplant recipients.
Res Commun Mol Pathol Pharmacol
November 2007
CYP 3A4 plays a vital role in the metabolism of many drugs including immunosuppressants. An association between a transition of A --> G at position -290 of the 5'-regulatory region of the CYP 3A4 gene and an effect on the level of transcription has been reported. The CYP 3A4-G variant frequency varies substantially in different populations.
View Article and Find Full Text PDFThe most common cardiovascular manifestation of Systemic Lupus Erythematosus is pericardial disease. Tamponade in SLE is rarely described. The patient discussed in this case report presented with symptoms of heart failure.
View Article and Find Full Text PDFInduction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure.
Am J Physiol Lung Cell Mol Physiol
August 2002
Collagen degradation is required for the creation of new integrin binding sites necessary for cell survival. However, a complete separation between the matrix and the cell leads to apoptosis, dilatation, and failure. Previous studies have demonstrated increased metalloproteinase activity in the failing myocardium.
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