Knowledge-Based Quality Assurance and Model Maintenance in Lung Cancer Radiation Therapy in a Statewide Quality Consortium of Academic and Community Practice Centers.

Purpose: Locally advanced lung cancer (LALC) treatment planning is often complex due to challenging tradeoffs related to large targets near organs at risk, making the judgment of plan quality difficult. The purpose of this work was to update and maintain a multi-institutional knowledge-based planning (KBP) model developed by a statewide consortium of academic and community practices for use as a plan quality assurance (QA) tool.

Methods And Materials: Sixty LALC volumetric-modulated arc therapy plans from 2021 were collected from 24 institutions.

Direct incorporation of patient-specific efficacy and toxicity estimates in radiation therapy plan optimization.

Purpose: Current radiation therapy (RT) treatment planning relies mainly on pre-defined dose-based objectives and constraints to develop plans that aim to control disease while limiting damage to normal tissues during treatment. These objectives and constraints are generally population-based, in that they are developed from the aggregate response of a broad patient population to radiation. However, correlations of new biologic markers and patient-specific factors to treatment efficacy and toxicity provide the opportunity to further stratify patient populations and develop a more individualized approach to RT planning.

Feasibility of function-guided lung treatment planning with parametric response mapping.

Purpose: Recent advancements in functional lung imaging have been developed to improve clinicians' knowledge of patient pulmonary condition prior to treatment. Ultimately, it may be possible to employ these functional imaging modalities to tailor radiation treatment plans to optimize patient outcome and mitigate pulmonary complications. Parametric response mapping (PRM) is a computed tomography (CT)-based functional lung imaging method that utilizes a voxel-wise image analysis technique to classify lung abnormality phenotypes, and has previously been shown to be effective at assessing lung complication risk in diagnostic applications.

3D dosimetric validation of ultrasound-guided radiotherapy with a dynamically deformable abdominal phantom.

Objectives: The purpose of this study was to dosimetrically benchmark gel dosimetry measurements in a dynamically deformable abdominal phantom for intrafraction image guidance through a multi-dosimeter comparison. Once benchmarked, the study aimed to perform a proof-of-principle study for validation measurements of an ultrasound image-guided radiotherapy delivery system.

Methods: The phantom was dosimetrically benchmarked by delivering a liver VMAT plan and measuring the 3D dose distribution with DEFGEL dosimeters.

Evaluation of a commercial deformable image registration algorithm for dual-energy CT processing.

Purpose: Several dual-energy computed tomography (DECT) techniques require a deformable image registration to correct for motion between the acquisition of low and high energy data. However, current DECT software does not provide tools to assess registration accuracy or allow the user to export deformed images, presenting a unique challenge for image registration quality assurance (QA). This work presents a methodology to evaluate the accuracy of DECT deformable registration and to quantify the impact of registration errors on end-product images.

An improved abdominal phantom for intrafraction image guidance validation.

A dynamically compressible phantom of the human abdomen that simulates organ motion with breathing is being developed for possible testing of image-gated beam delivery in radiotherapy. The polyvinyl chloride plastisol (PVCP) phantom features a cavity that can contain a deformable normoxic polyacrylamide gel (nPAG) dosimeter that is intended for use with MRI to provide dosimetric data. The phantom has been improved by the inclusion of new components that are more realistic anatomically and exhibit CT values similar to those of the tissues they mimic.

Deformable abdominal phantom for the validation of real-time image guidance and deformable dose accumulation.

Purpose: End-to-end testing with quality assurance (QA) phantoms for deformable dose accumulation and real-time image-guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a deformable abdominal phantom containing a deformable three-dimensional dosimeter that could provide robust testing of these systems.

Methods: The deformable abdominal phantom was fabricated from polyvinyl chloride plastisol and phantom motion was simulated with a programmable motion stage and plunger.

Technical Note: Characterization of clinical linear accelerator triggering latency for motion management system development.

Purpose: Latencies for motion management systems have previously been presented as guidelines for system development and implementation. These guidelines consider the overall system latency, including data acquisition, algorithm processing, and linac triggering time. However, during system development, the triggering latency of the clinical linear accelerator is often considered fixed.