Publications by authors named "Charles K Lok"
Article Synopsis
- Cytokines are crucial in immune responses to various medical conditions, but an imbalance between inflammatory and anti-inflammatory cytokines can cause serious health issues.
- The study introduces antibody-modified conduits (AMCs), which are innovative blood-filtering devices that can selectively remove harmful cytokines from blood samples in a lab setting.
- Researchers tested AMCs in vivo on rats to effectively filter out interleukin 1 β in cases of hypercytokinemia, showcasing their potential for therapeutic applications.
Direct Mannich-Type Reactions Promoted by Frustrated Lewis Acid/Brønsted Base Catalysts.
Angew Chem Int Ed Engl
October 2016
Direct Mannich-type reactions that afford both α- and β-amino esters by the reaction of a broad range of carbonyl compounds and aldimines are disclosed. The transformation is promoted by a sterically frustrated Lewis acid/Brønsted base pair, which is proposed to operate cooperatively: Within the catalyst complex, an enolate is generated that then reacts with a hydrogen-bond-activated imine. Noncovalent interactions between reactants and the catalyst provide selectivity and new opportunities for future catalyst design.
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