Metabolic abnormalities among free-ranging Macaca mulatta on Cayo Santiago: Comparisons with Macaca mulatta at Sabana Seca.

Free-ranging rhesus macaques (Macaca mulatta) were examined on the island of Cayo Santiago (CS), Puerto Rico, with intravenous glucose tolerance tests (IV-GTTs). Results were compared to monkeys derived from the island, but subsequently housed in corrals or gang cages at Sabana Seca (SS). Glucose clearance was similar among CS and SS macaques (range 2.

Effects of physical and chemical restraint on intravenous glucose tolerance test in crested black macaques (Macaca nigra).

The effects of physical and chemical restraint on glucose clearance and insulin secretion were evaluated during intravenous glucose tolerance testing in Macaca nigra. Conscious monkeys placed in plexiglas cylindrical restraining devices (CRD) appeared relaxed, but glucose clearance and insulin secretion were impaired. A combination of midazolam with ketamine, compared to ketamine alone, did not cause detectable changes in the intravenous glucose tolerance tests; midazolam also reduced adverse reactions to ketamine and extended the duration of anesthesia.

Carbohydrate impairment and insulin secretory abnormalities among Macaca mulatta from Cayo Santiago.

Rhesus macaques (Macaca mulatta) from Cayo Santiago were examined for evidence of carbohydrate intolerance indicative of potential development of non-insulin-dependent diabetes mellitus (NIDDM). Monkeys 6 to >20 years from natal Groups J, M, and P, an AGED Group (all >20 years), and unrelated monkeys removed from the island in association with other groups (CAYO), were examined with intravenous glucose tolerance tests (iv-GTT). Morphometric measurements were made on all tested monkeys.