Publications by authors named "Charles Dzviga"
Background: Skin exposure to chemicals may induce an inflammatory disease known as contact dermatitis (CD). Distinguishing the allergic and irritant forms of CD often proves challenging in the clinic.
Methods: To characterize the molecular signatures of chemical-induced skin inflammation, we conducted a comprehensive transcriptomic analysis on the skin lesions of 47 patients with positive patch tests to reference contact allergens and nonallergenic irritants.
Introduction: Basophils play a major physio-pathological role in hypersensitivity related diseases. Basophils express high affinity Immunoglobulin (Ig) E receptors (FcεRI), IgG and complement regulatory. Basophils also have immunoregulatory activity through interaction with T cells.
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- - The study investigated immediate hypersensitivity reactions (IH) to iodinated and gadolinium-based contrast media (ICM; GBCM), focusing on differentiating between allergic and non-allergic responses, which is crucial for future medical treatment decisions.
- - Over 245 patients were analyzed through skin tests and other clinical evaluations, revealing an allergic reaction rate of 19.6% for ICM and 27.8% for GBCM, with notable cross-reactivity among patients.
- - The findings indicated that allergic IH was linked to more severe reactions and quicker onset than non-allergic IH, highlighting the need for more sensitive skin testing methods to better identify allergic responses to contrast agents.
Introduction: Venom immunotherapy (VIT) is the only efficient prevention for sting-induced anaphylaxis, but its application is not without risks and needs precautions and standardization. European guidelines were proposed in 2005, but recent practice surveys and more recent knowledge raise the need for an update. The aim of this study was to analyze VIT practices in France, based on previous surveys in Europe but also extended to outcome event management.
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