Publications by authors named "Charles David Stout"
Proc Natl Acad Sci U S A
March 2013
Article Synopsis
- Amphiphile selection is vital for studying membrane proteins (MPs), and a new family of steroid-based facial amphiphiles (FAs) has been developed to improve this process.
- These FAs stabilize MPs and create smaller protein-detergent complexes (PDCs), which are advantageous for MP crystallization.
- Successful crystallization of various MPs, such as connexin 26 and MsbA, was achieved using FAs alone or in combination with other detergents or lipids, highlighting their effectiveness in enhancing crystallizability compared to traditional detergents.
