Publications by authors named "Charles C Cunningham"
Article Synopsis
- The study compared 158 children: 44 with selective mutism (SM), 65 with mixed anxiety (MA), and 49 controls, focusing on their behavioral and emotional functioning.
- Children with SM showed lower social skills than controls, but there were not many significant differences between the SM and MA groups regarding social skills and anxiety, except for higher ratings of social anxiety in those with SM.
- The results suggest that SM should be seen as an anxiety disorder with notable social functioning deficits, leading to recommendations for incorporating social skills training in treatments for both SM and anxiety disorders.
Talabostat mesilate is an orally active, specific inhibitor of dipeptidyl peptidases, including tumor-associated fibroblast activation protein. However, by an independent mechanism, talabostat also stimulates the upregulation of cytokines and chemokines to engender a tumor-specific host immune response, thus giving it a unique dual mechanism of action. In clinical trials, talabostat has demonstrated significant activity, including achieving complete responses in patients with non-small-cell lung cancer and malignant melanoma.
View Article and Find Full Text PDFPurpose: To determine the maximum-tolerated dose (MTD), efficacy, safety, and pharmacokinetics of oblimersen sodium in patients with advanced chronic lymphocytic leukemia (CLL).
Patients And Methods: Eligible patients had relapsed or refractory CLL after treatment with fludarabine. Oblimersen was administered at doses ranging from 3 to 7 mg/kg/d as a 5-day continuous intravenous infusion in cycle 1 and as a 7-day continuous intravenous infusion in subsequent cycles every 3 weeks in stable or responding patients.