Publications by authors named "Charles B De Koning"
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Synopsis of recent research by authors named "Charles B De Koning"
- Charles B De Koning's recent research primarily focuses on the design and synthesis of novel compounds aimed at inhibiting key enzymes associated with malaria and cancer, including Plasmodium falciparum dihydrofolate reductase and calcium-dependent protein kinases.
- His work demonstrates promising biological activity of newly synthesized pyrimidine derivatives and copper-imidazo compounds in vitro, showcasing their potential as effective inhibitors against resistant strains of malaria and leukemia cells.
- De Koning also explores innovative synthetic methodologies, such as demethylative lactonization and photochemically-mediated cyclization, to enhance the efficiency and yield of biologically active compounds, including lamellarin derivatives and jadomycin alkaloids.
