Systematic variation of microtopography, surface chemistry and elastic modulus and the state dependent effect on endothelial cell alignment.

We examined how variations in elastic modulus, surface chemistry and the height and spacing of micro-ridges interact and effect endothelial cell (EC) alignment. Specifically, we employed independent control of the surface properties in order to elucidate the relative importance of each factor. Polydimethylsiloxane elastomer (PDMSe) was fabricated with 1.

Polyvinylpyrrolidone modified bioactive glass fibers as tissue constructs: in vitro mesenchymal stem cell response.

The sol-gel synthesis of a bioactive glass (BAG) sol with the incorporation of polyvinylpyrrolidone and the subsequent spraying of short, discontinuous fibers is reported. The incorporation of the polymer into the BAG sol allowed for increased control of the rheological properties and resulted in a more homogeneous fibrous material when sprayed through an air gun. Reaction kinetics and sol viscosity were monitored and analyzed during synthesis, and fibers were characterized using scanning electron microscopy and thermal analysis.