Publications by authors named "Charles A Seabury"
Pathol Res Pract
December 2024
Article Synopsis
- A significant portion of prostate cancer cases may have a hereditary link, prompting a study into germline pathogenic variants among patients.
- Among 160 prostate cancer patients tested, 12% were found to have pathogenic variants in various genes, with no notable differences in clinicopathologic characteristics between those with and without these variants.
- The study highlighted that patients with a family history of cancer were more likely to possess these genetic variants, suggesting a need for further research with larger samples to explore the connections between genetic and clinical data.
Article Synopsis
- The study aims to create a more specific test for prostate cancer, moving away from the prostate-specific antigen (PSA) test, which can cause unnecessary biopsies due to lack of specificity.
- Researchers evaluated antibody titers from 67 unique peptide sequences in men with and without prostate cancer, finding 3 peptides that showed significant differences between the two groups.
- While the new test demonstrated a low sensitivity (44% for detecting cancer), it showed a high specificity (94% for correctly identifying non-cancer patients), suggesting it could be a reliable method for distinguishing prostate cancer.
