The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis.

Background: In 2011, supported by data from two separate trauma centers, we implemented a protocol to administer tranexamic acid (TXA) in trauma patients with evidence of hyperfibrinolysis (HF) on admission. The purpose of this study was to examine whether the use of TXA in patients with HF determined by admission rapid thrombelastography was associated with improved survival.

Methods: Following institutional review board approval, we evaluated all trauma patients 16 years or older admitted between September 2009 and September 2013.