Significance: Topical latanoprostene bunod increases capillary oxygen saturation and blood volume at the optic nerve head in healthy individuals.
Purpose: This study aimed to evaluate the effect of topical latanoprostene bunod on optic nerve blood volume and oxygen saturation in a population of healthy participants.
Methods: In this prospective double-blind crossover study, 23 healthy participants aged from 21 to 62 years were recruited.