Publications by authors named "Charlaine A Aventurado"
Article Synopsis
- Fenpropathrin, a widely used pyrethroid insecticide, disrupts voltage-gated sodium channels, leading to paralysis in target animals, but its effects on peripheral organs, particularly the cardiovascular system, have been under-researched.
- The study used zebrafish larvae to assess cardiac function following fenpropathrin exposure, measuring heart rate and blood flow, and found significant changes in cardiac parameters and vascular structure with increasing doses.
- Molecular docking analyses indicated fenpropathrin binds strongly to cardiac sodium channels, leading to cardiomegaly, and suggests a critical need for more research on this pesticide's health effects.
BCR-ABL, a fusion protein kinase, is a druggable target exclusively expressed in patients with chronic myeloid leukemia (CML). Several anti-leukemia medicines targeting this protein have been developed in recent years. However, therapeutic options are limited for CML patients bearing multiple BCR-ABL1 mutations.
View Article and Find Full Text PDFp-Toluene sulfonamide (p-TSA), a small molecular drug with antineoplastic activity is widely gaining interest from researchers because of its pharmacological activities. In this study, we explored the potential cardio and neural toxicity of p-TSA in sublethal concentrations by using zebrafish as an in vivo animal model. Based on the acute toxicity assay, the 96hr LC was estimated as 204.
View Article and Find Full Text PDFIntroduction: Cancer is considered as one of the deadliest human diseases today. Angiogenesis, the propagation of new blood vessels from pre-existing vasculature, is a critical step in the progression of cancer as it is essential in the growth and metastasis of tumors. Hence, suppression of angiogenesis is a promising approach in cancer therapy.
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