Publications by authors named "Charla E"
Atherosclerosis is a major cardiovascular disease and in 2016, the World Health Organisation (WHO) estimated 17.5 million global deaths, corresponding to 31% of all global deaths, were driven by inflammation and deposition of lipids into the arterial wall. This leads to the development of plaques which narrow the vessel lumen, particularly in the coronary and carotid arteries.
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- * The study aimed to determine the role of the KLK6 protease in this disease by creating double knockout mice that lacked both Spink5 and Klk6 genes.
- * Findings showed that while removing Klk6 significantly reduced skin inflammation markers like Tslp, it did not improve skin shedding or prevent the lethal effects of NS, suggesting KLK6 may be a target for treating skin inflammatory conditions.