Unmet Needs of Persons with Down Syndrome: How Assistive Technology and Game-Based Training May Fill the Gap.

The use of new technology seems to be an important factor that contributes to the overall ability to adapt and achieve higher independence. Technologies using digital games have gained the great interest of the scientific community as there are many advantages for both effectiveness and benefits, physically and mentally, providing the opportunity for essential and enjoyable training. This study presents an important initial step utilizing the LLM Care service which focuses on the needs and challenges for the health and daily living of people with Down syndrome (DS) by applying new technology hardware and software.

The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome.

Congenital heart defect (CHD) occurs in 40% of Down syndrome (DS) cases. While carrying three copies of chromosome 21 increases the risk for CHD, trisomy 21 itself is not sufficient to cause CHD. Thus, additional genetic variation and/or environmental factors could contribute to the CHD risk.