Publications by authors named "Charbotel B"

Unlabelled: The Hospital Anxiety and Depression Scale (HADS) is commonly used to detect depressive or anxious states, but its 14-item questionnaire is time-consuming. Visual analog scales (VAS) are easy to use and quick to implement. Although the VAS has been validated to assess pain and occupational stress, VAS scores for anxiety and mood have never been evaluated in the workplace.

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Article Synopsis
  • Next-generation sequencing techniques, like whole-exome and error-corrected sequencing, are used to analyze mutation patterns in both cancerous and non-cancerous tissues.
  • The review emphasizes the potential of using these techniques on archived tissue samples fixed in formalin or alcohol to identify mutational signatures that reflect prior exposure to mutagens.
  • By distinguishing between DNA damage from tissue fixation and true biological mutations, this research helps improve our understanding of cancer causes and supports prevention strategies aimed at reducing exposure to cancer risk agents.
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Introduction: According to the 2018-2019 People Mobility Survey, work-related journeys (commuting and on-duty journeys) account for approximately 25% of all journeys. The use of non-motorised (nm) and motorised (m) personal mobility devices (PMDs) has steadily increased since their introduction into the French market in the last decade.

Objective: This study aimed to describe the characteristics of work-related road accidents and their evolution since the introduction of new PMDs in France and the increase in the use of scooters.

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Introduction: The occupational road-accident risk on public roads and the work conditions for professional driving is still an important issue in occupational health despite lower road-accident rates. This study presents the evolution over time of the work-related constraints for these employees based on the Sumer surveys carried out in 2003, 2010 and 2017.

Method: Data from the 2010 and 2017 surveys were restricted to match the scope of the 2003 survey in order to enable prevalence data to be compared in equivalent populations.

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Background: While overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialized countries, especially in non-smoking and non-drinking patients.

Case Presentation: We document a case of gingiva SCC in a 56 years old never-smoker patient reporting low alcohol consumption and unusual occupational solvent exposure. The HPV-negative lesion was surgically removed in 2018, and the patient remains in complete remission 4 years after recurrent surgery in 2019.

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Objectives: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.

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Background: Burnout is a public health problem with various health consequences, among which cardiovascular disease is the most investigated but still under debate. Our objective was to conduct a systematic review and meta-analysis on the influence of burnout on cardiovascular disease.

Methods: Studies reporting risk (odds ratio, relative risk, and hazard ratio) of cardiovascular disease following burnout were searched in PubMed, PsycINFO, Cochrane, Embase, and ScienceDirect.

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Background: Regional Centers for Occupational and Environmental Pathologies (CRPPE) are responsible for identifying possible occupational etiologies of pathologies. When an occupational origin is determined, an Initial Medical Certificate (IMC) is given to the patient to allow him to initiate a procedure for recognition as an occupational disease (OD) by his health insurance organization.

Objectives: The main aim of this study was to investigate the outcome of occupational disease claims in patients who received an IMC delivered by the CRPPE of Lyon.

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Introduction: Residential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This study aimed to investigate the impact of radon exposure on the survival of lung cancer patients.

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Background: The endocrine-disrupting effects of phytopharmaceutical active substances (PAS) on human health are a public health concern. The CIPATOX-PE database, created in 2018, listed the PAS authorized in France between 1961 and 2014 presenting endocrine-disrupting effects for humans according to data from official international organizations. Since the creation of CIPATOX-PE, European regulations have changed, and new initiatives identifying substances with endocrine-disrupting effects have been implemented and new PAS have been licensed.

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Background: Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.

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Objectives: This study aims to present an overview of the formal recognition of COVID-19 as occupational disease (OD) or injury (OI) across Europe.

Methods: A COVID-19 questionnaire was designed by a task group within COST-funded OMEGA-NET and sent to occupational health experts of 37 countries in WHO European region, with a last update in April 2022.

Results: The questionnaire was filled out by experts from 35 countries.

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Background: Road accidents are the leading type of work-related fatalities, but the impact of work-related travel on overall traffic safety has been scarcely studied.

Objective: The main objective of the present study was to assess drivers' relative road accident risk between work-related and personal journeys.

Methods: A responsible/non-responsible case-control study was performed on a sample of 7,051 road accidents in France from the VOIESUR project.

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Article Synopsis
  • The study investigates the link between parental occupational exposure to solvents and the risk of testicular germ cell tumors (TGCT) in their sons, focusing on environmental risk factors during pregnancy.
  • The research involved a nationwide case-control study in France with 454 TGCT cases and 670 controls, assessing parental job exposure to various solvents through structured interviews and job-exposure matrices.
  • Findings indicated a slight increase in TGCT risk associated with paternal exposure to certain solvents, particularly trichloroethylene, and a higher risk for men born in the 1970s with maternal exposure to fuels, but overall no strong connection between solvent exposure and TGCT was established.
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Police personnel are among the first responders exposed to terrorist attacks, raising in number in the late decades. Due to their profession, they are also exposed to repetitive violence, increasing their vulnerability to PTSD and depression. Our study aims at comparing the prevalence of PTSD and depression, and the risk factors associated with these conditions among directly and indirectly exposed versus non-exposed police personnel during the Strasbourg Christmas Market terrorist attack.

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  • Testicular germ cell tumors (TGCT) are the most common cancer in young men and their incidence has significantly increased over the past 40 years, prompting this study to investigate the link between certain occupations and TGCT risk in men aged 18-45.
  • The TESTIS study, conducted in metropolitan France from 2015 to 2018, included 454 TGCT cases and 670 controls, collecting comprehensive job histories, and analyzed the data using statistical methods to estimate odds ratios for different occupations.
  • Results indicated a higher TGCT risk in agricultural workers, salesmen, and electrical fitters, suggesting the need for further research to uncover specific agents or chemicals contributing to this increased risk in these professions.
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Introduction: Few studies are available on the health status of doctoral students. This position at the border between university studies and a professional activity presents specific risk factors, especially in terms of psychosocial constraints. The lockdowns implemented worldwide to control the COVID-19 pandemic are potentially worsening factors.

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Objective: This study investigated the association between occupational asbestos exposure (OAE) and survival in patients with histologically confirmed lung cancer (LC).

Methods: This monocentric study was conducted in the Comprehensive Cancer Centre Léon Bérard, Lyon, France. A systematic screening has been in place since 2014 for occupational exposure to carcinogens using a self-assessment questionnaire sent to all patients newly diagnosed with histologically confirmed LC identified through the multidisciplinary LC board from 2014 to 2019.

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  • Occupational lung cancer cases are often under-reported and under-compensated, prompting a study to improve detection and compensation through systematic screening of occupational exposures.
  • A self-administered questionnaire was used to gather job history and exposure data from lung cancer patients, with physician assessments leading to specialized consultations for those with potential occupational links.
  • The study found that out of 1251 patients surveyed, a significant portion attended consultations, revealing that many had been exposed to occupational lung carcinogens and subsequently received medical certificates and compensation, highlighting the effectiveness of this screening approach.
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  • Traffic road crashes are a major cause of workplace fatalities, with a specific focus on commuting accidents, which are less studied.
  • This study aimed to analyze the incidence of commuting accidents among non-physician professionals at a French university hospital over five years, considering factors like gender and job category.
  • Findings revealed a significant variation in accident rates across job categories, with service agents and auxiliary nurses having a higher risk compared to administrative staff, potentially linked to work-related fatigue and long commutes.
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Objective: We aimed to assess the prevalence of exposure by sector and the sectors of activity most exposed to each exposure, using routine occupational health data, and to quantify the risk of being exposed.

Method: Occupational risk factors were assessed by workers followed by the Occupational Health Service of Cher, using self-reported questionnaires. The sectors of activity were grouped into seven sectors, and the risks were grouped into six occupational exposure groups.

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Background: Diffuse interstitial lung diseases (ILD) constitute a heterogeneous group of conditions with complex etiological diagnoses requiring a multidisciplinary approach. Much is still unknown about them, particularly their relationship with occupational exposures. The primary objective of this study was to investigate the distribution of occupational exposures according to type of ILD.

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Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring.

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