Application of Machine Learning to Optimize Management of Children in Hospital with Lower Respiratory Tract Infection.

Effective triage can help optimize the use of limited healthcare resources for managing paediatric patients with lower respiratory tract infection (LRTI), the primary cause of death worldwide for under 5 years old children. However, triage decisions do not consider medium to long term needs of hospitalized children. In this study, we aim to leverage data-driven methods using objective measures to predict the type of hospital stay (short or long).

Supervised learning strategy for classification and regression tasks applied to aeronautical structural health monitoring problems.

This paper presents the use of a kernel-based machine learning strategy targeting classification and regression tasks in view of automatic flaw(s) detection, localization and characterization. The studied use-case is a structural health monitoring configuration with an array of piezoelectric sensors integrated on aluminium panels affected by flaws of various positions and dimensions. The measured guided wave signals are post processed with a guided wave imaging algorithm in order to obtain an image representing the health of each specimen.

Guided wave imaging of composite plates using passive acquisitions by fiber Bragg gratings.

In this paper, imaging results of defects in composite plates using guided wave-based algorithms, such as delay and sum and Excitelet, are presented. Those algorithms are applied to passive data for which the signal corresponding to each emitter-receiver couple is recovered as a result of the cross correlation of the ambient noise measured simultaneously by the two sensors. The transition to passive imaging allows the use of lighter sensors that are unable to emit ultrasonic waves, such as fiber Bragg gratings (FBGs) sensors on optical fibers, which are used in this study.

Selective abolition of Mayer waves in conscious endotoxemic rats.

The relation between vascular sympathetic tone and the amplitude of arterial pressure (AP) Mayer waves was examined by analyzing 60-min recordings of AP and renal sympathetic nerve activity (RSNA) obtained in conscious rats before and after lipopolysaccharide administration, which results in strong sympathoexcitation. Mayer waves completely disappeared together with accompanying oscillations of RSNA. Meanwhile, the gain of the sympathetic baroreceptor reflex was increased, thus suggesting that abolition of Mayer waves resulted from the previously reported reduction of vascular reactivity to α-adrenoceptor stimulation.

Passive guided wave tomography for structural health monitoring.

In this paper the authors present a baseline-free quantitative method for imaging corrosion flaws in thin plates. It only requires an embedded guided wave sensor network used in a fully passive way, i.e.

Open-CSAM, a new tool for semi-automated analysis of myofiber cross-sectional area in regenerating adult skeletal muscle.

Adult skeletal muscle is capable of complete regeneration after an acute injury. The main parameter studied to assess muscle regeneration efficacy is the cross-sectional area (CSA) of the myofibers as myofiber size correlates with muscle force. CSA analysis can be time-consuming and may trigger variability in the results when performed manually.

Passive guided waves measurements using fiber Bragg gratings sensors.

Guided elastic waves are often studied as an effective solution for Structural Health Monitoring (SHM) systems of plate-like structures thanks to the capacity to propagate on large distances. In typical applications such as monitoring delaminations in aircraft fuselage, a network made of piezoelectric transducer (PZT) is used to emit and receive such waves in the structure. Fiber Bragg grating (FBG) sensors on optical fibers are a promising alternative to PZT for guided waves measurements in practical applications due to the capacity for dense multiplexing and robustness with respect to the environment.

Multichannel Multiple Signal Classification for dispersion curves extraction of ultrasonic guided waves.

Multichannel acquisition of ultrasonic guided waves can be used to extract dispersion curves, from the time-position domain (t-x) to the frequency-wavenumber (f-k), or frequency-velocity domain (f-c). Accurate measurements are needed in order to be able to precisely characterize the specimen, by improving the extraction of low amplitude modes and enhance resolution. The proposed method is based on the MUltiple SIgnal Classification algorithm combined with a multi-emitter and multi-receiver acquisition.

Age-dependent ventricular arrhythmias risk, structural and molecular remodeling in systemic arterial hypertension.

Introduction: The left ventricular hypertrophy (LVH)-ventricular arrhythmias relationship associated with arterial hypertension and aging remains controversial. We aimed to assess the age-dependency of ventricular arrhythmias in spontaneously hypertensive rats (SHRs) and the corresponding ventricular structural and molecular remodeling.

Materials And Methods: Ventricular arrhythmias were quantified using 24-h radiotelemetry ECG monitoring in eight SHRs and four Wistar-Kyoto (WKY) rats at 14 (young), 24 (adult), and 48 (aging) weeks of age.

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

Atrial fibrillation (AF) is the most common cardiac arrhythmia. As the molecular mechanisms underlying the pathology are largely unknown, this cardiac arrhythmia remains difficult to treat. To identify specific molecular actors involved in AF, we have performed a transcriptomic analysis on left atrium (LA) from patients with valvular heart disease with or without AF.

Assessment of cardiac autonomic tone in conscious rats.

Cardiac autonomic tone can be assessed either by estimating separately vagal and sympathetic tones or by evaluating the net effect of their interaction, the so-called sympathovagal balance (SVB). To compare the most commonly used methods in rats, telemetric recordings of the electrocardiogram were performed in normotensive WKY rats, and in groups of spontaneously hypertensive (SHR) rats that were either untreated or chronically treated with the cholinesterase inhibitor, pyridostigmine, to enhance vagal tone. Cardiac autonomic blockers were administered alone and in combination, so that heart rate (HR) could be measured (1) under resting conditions, (2) with either autonomic branch blocked, and (3) with both branches blocked (which provided intrinsic HR, iHR).

Pyridostigmine enhances atrial tachyarrhythmias in aging spontaneously hypertensive rats.

This study examined whether chronic administration of pyridostigmine, a reversible cholinesterase inhibitor, would exacerbate episodes of spontaneous atrial tachyarrhythmia (AT) in conscious, aging, spontaneously hypertensive rats (SHRs). Telemetric recordings of electrocardiogram (ECG, n = 5) and ECG/arterial pressure (n = 3) were performed in male 49-week old SHRs. After a 1-week period of continuous recording under baseline conditions, rats were implanted with osmotic minipumps that delivered pyridostigmine (15 mg/kg/day subcutaneously) for either 1 (n = 8) or 3 (n = 5) weeks.

Unprovoked atrial tachyarrhythmias in aging spontaneously hypertensive rats: the role of the autonomic nervous system.

Experimental models of unprovoked atrial tachyarrhythmias (AT) in conscious, ambulatory animals are lacking. We hypothesized that the aging, spontaneously hypertensive rat (SHR) may provide such a model. Baseline ECG recordings were acquired with radiotelemetry in eight young (14-wk-old) and eight aging (55-wk-old) SHRs and in two groups of four age-matched Wistar-Kyoto (WKY) rats.

Effect of chronic cervical ganglionectomy on the spontaneous variability of internal carotid blood flow in the conscious rat.

The role of sympathetic innervation in the control of spontaneous fluctuations of cerebral blood flow is still poorly understood. In conscious, unrestrained rats, blood flow velocity (pulsed Doppler) was measured in both internal carotid arteries 1 week after either excision of the right superior cervical ganglion (n = 8) or sham surgery (n = 6). Using Fourier-based techniques, spectral power of each carotid blood flow (CBF) was computed over the whole recording period (246 min), which was segmented into nine consecutive 27.

Role of the sympathetic nervous system in cerebrovascular responses to air-jet stress in rats.

This study examined the role of sympathetic nerves in the control of cerebral hemodynamics during air-jet stress. In adult male Sprague-Dawley rats, blood flow velocity (pulsed Doppler) was measured in both internal carotid arteries 1 week after excision of one superior cervical ganglion. Blood pressure (BP) and carotid blood flows (CBFs) were simultaneously recorded during exposure to air-jet stress.

Outcome and risk factors for late-onset complications 24 months beyond allogeneic hematopoietic stem cell transplantation.

Objectives: The aim of this retrospective study was to assess the incidence of late complications occurring ≥2 years after allogeneic hematopoietic stem cell transplantation (HSCT) for malignant diseases using a T-cell depletion strategy.

Methods: Between 1984 and 2004, 142 patients were eligible for the study. Total body irradiation (TBI) was carried out in 85% of the patients and T-cell depletion in 84%.

Time-frequency analysis of the baroreflex control of renal sympathetic nerve activity in the rat.

Cross-spectral analysis using the short-time Fourier transform (STFT) allows estimating the transfer function between spontaneous fluctuations of arterial pressure (AP) and renal sympathetic nerve activity (RSNA) at the heart rate (HR) frequency, which provides an index of sympathetic baroreflex sensitivity (sBRS) in rats. The method, however, cannot reliably compute more than one value per min. The goal of the present study was to achieve a better temporal resolution by using advanced methods.

Excitation and focusing of Lamb waves in a multilayered anisotropic plate.

The radiation of Lamb waves by an axisymmetric source on the surface of an anisotropic plate is investigated. An analytical expression of the Green's function, valid in the far field domain, is derived. This approximation shows that the anisotropy of the propagation medium induces a focusing of Lamb modes in some directions, which correspond to minima of the slowness.

Very high frequency components of renal sympathetic nerve activity in conscious rats.

The aim of this study was to examine whether multifibrenal sympathetic nerve activity (RSNA) of conscious rats contains frequency components of biological interest at frequencies above 25Hz. RSNA was recorded in 10 conscious Sprague-Dawley rats under baseline conditions and during infusion of vasoactive drugs that reflexly altered the mean RSNA level. The RSNA signal was band-pass filtered (300-3000Hz) before being sampled at 10,000Hz.

Quality of life and social integration after allogeneic hematopoietic SCT.

In total, 124 adult patients in remission after allogeneic hematopoietic SCT (HSCT) participated in a cross-sectional study to assess health-related quality of life (HRQL). Assessment of HRQL was carried out using two questionnaires: the (EORTC QLQ-C30) and the Functional Assessment of Cancer Therapy (FACT) with specific modules for BMT (FACT-BMT). Transplanted patients differed from healthy controls in many HRQL-related dimensions in the EORTC QLQ-C30: social functioning 73.

Baroreflex control of lumbar and renal sympathetic nerve activity in conscious rats.

This study compared the baroreflex control of lumbar and renal sympathetic nerve activity (SNA) in conscious rats. Arterial pressure (AP) and lumbar and renal SNA were simultaneously recorded in six freely behaving rats. Pharmacological estimates of lumbar and renal sympathetic baroreflex sensitivity (BRS) were obtained by means of the sequential intravenous administration of sodium nitroprusside and phenylephrine.

A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats.

The present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic baroreflex sensitivity (BRS). AP and RSNA were simultaneously recorded in conscious rats, either baroreceptor-intact (control, n = 11) or with partial denervation of baroreflex afferents [aortic baroreceptor denervated (ABD; n = 10)] during 1-h periods of spontaneous activity. Transfer gain was calculated over 58 adjacent 61.

Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature.

Background: Disseminated aspergillosis is thought to occur as a result of vascular invasion from the lungs with subsequent bloodstream dissemination, and portals of entry other than sinuses and/or the respiratory tract remain speculative.

Methods: We report two cases of primary aspergillosis in the digestive tract and present a detailed review of eight of the 23 previously-published cases for which detailed data are available.

Results And Conclusion: These ten cases presented with symptoms suggestive of typhlitis, with further peritonitis requiring laparotomy and small bowel segmental resection.

Transfer function analysis between arterial pressure and renal sympathetic nerve activity at cardiac pacing frequencies in the rat.

This study examined the possible influence of changes in heart rate (HR) on the gain of the transfer function relating renal sympathetic nerve activity (RSNA) to arterial pressure (AP) at HR frequency in rats. In seven urethane-anesthetized rats, AP and RSNA were recorded under baseline conditions (spontaneous HR = 338 +/- 6 beats/min, i.e.

Human CD34+ CD11b- cord blood stem cells generate in vitro a CD34- CD11b+ subset that is enriched in langerin+ Langerhans dendritic cell precursors.

Objective: We investigated whether the expression of CD11b on precursors derived in vitro from CD34+ hematopoietic stem cells was related to their ability to generate CD11b- and CD11b+ Langerhans dendritic cells (LC).

Methods: Human CD34+ cells purified from cord blood were cultured with FLT3 ligand, thrombopoietin, and stem cell factor (FTS) for 2 weeks, analyzed, and sorted by FACS. Sorted fractions were cultured as above, or differentiated into LC with GM-CSF, IL-4, and TGF-beta1 (G4-TGF) for 6 days.