Publications by authors named "Chapman R"

The decathlon is a 10-event discipline in the sport of track and field, typically offered only for men at the elite level of competition (heptathlon is the complementary event for women). It is composed of 10 distinct events contested over 2 days. Using event-specific coefficients, marks are converted to scores, which sum to produce an overall score.

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Background: Many studies have examined the prevalence of acetabular version (AV) and femoral version (FV) abnormalities and their effect on patient-reported outcomes (PROs) after hip arthroscopy for femoroacetabular impingement syndrome (FAIS), but few have explored the prevalence and influence of combined version (CV) abnormalities.

Purpose: To (1) describe the distribution of AV, FV, and CV in the largest cohort to date and (2) determine the relationship between AV, FV, and CV and PROs after hip arthroscopy for FAIS.

Study Design: Cohort study; Level of evidence, 3.

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Optical quantum communication technologies are making the prospect of unconditionally secure and efficient information transfer a reality. The possibility of generating and reliably detecting quantum states of light, with the further need of increasing the private data-rate is where most research efforts are focusing. The physical concept of entanglement is a solution guaranteeing the highest degree of security in device-independent schemes, yet its implementation and preservation over long communication links is hard to achieve.

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Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. When a child is diagnosed with both PSC and inflammatory bowel disease (IBD), evidence-based information on counseling families and risk management of developing cholangiocarcinoma is limited. In this case series (PubMed/collaborators), we included patients with PSC-IBD who developed cholangiocarcinoma and contacted authors to determine an event curve specifying the time between the second diagnosis (IBD or PSC) and a diagnosis of cholangiocarcinoma.

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Importance: Communicating clearly about who is included in a population group is a critical element to effective dissemination and knowledge transfer. This narrative review highlights the inconsistency as it relates to communicating about individuals with intellectual disability (ID) and developmental disability (DD).

Observations: There is enormous variability in the use of definitions and abbreviations in the field of intellectual disability and developmental disabilities.

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Article Synopsis
  • Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have a significant risk of developing colorectal cancer, and there's no consensus on the best surveillance methods.
  • A study analyzed 91 patients with PSC and IBD over ten years to evaluate how effective chromoendoscopy and high-definition endoscopy were in detecting neoplastic lesions during regular check-ups.
  • Results showed that chromoendoscopy greatly increased the detection rate of neoplasia (by 5.58 times), while high-definition endoscopy also improved detection, but its significance diminished when factoring in chromoendoscopy.
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Purpose: To identify structures at risk during proximal adductor longus repair and to report observed distances between these structures and the adductor longus (AL) footprint.

Methods: Eight hemipelves from fresh cadaver whole-body specimens were dissected using a previously established surgical approach. The tendinous attachment of the AL was scored into the underlying bone and the footprint size was measured in millimeters.

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The presence of two chlorine atoms in 1,2-dichloroethene allows for isomerization around the double bond. This isomerization can lead to rich photochemistry. We present a time-resolved pump-probe photoelectron spectroscopy measurement on both the - and - isomers of 1,2-dichloroethene.

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The Sugen 5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) demonstrates most of the distinguishing features of PAH in humans, including increased wall thickness and obstruction of the small pulmonary arteries along with plexiform lesion formation. Recently, significant advancement has been made describing the epidemiology, genomics, biochemistry, physiology, and pharmacology in Su/Hx challenge in rats. For example, there are differences in the overall reactivity to Su/Hx challenge in different rat strains and only female rats respond to estrogen treatments.

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Trials should be designed with consideration of the individual disease context and research question. Many different approaches may be justified. In this chapter, we therefore consider some of the principal components of trial design in general and within the context of the emerging field of gene and cell therapies.

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Article Synopsis
  • An effective HIV vaccine is a critical goal for controlling the virus, aiming to provoke strong and lasting antibody responses.
  • A new nanoparticle (NP)-based vaccine using HIV envelope glycoproteins (Env) was developed through the SpyCatcher/SpyTag system, showing better immunogenicity compared to traditional soluble Env.
  • The study confirmed the successful assembly of these nanoparticles with unique Env structures and demonstrated promising immunogenicity results in rabbits following a specific vaccination regimen.
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Early intervention in problem sexual behavior (PSB) is critical; however, little is known about the engagement of children and families in therapeutic intervention for PSB. This research explored the characteristics, presenting issues, and engagement of 242 children aged 4-12 years attending a therapeutic service for PSB. Most frequently, PSB occurred within sibling relationships.

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Background: The manifestation of complex trauma results from exposure to severe and repetitive stressors occurring within the caregiver system. Frequently associated with child maltreatment, complex trauma can lead to impairments in multiple domains, including attachment, affect and behavioural regulation, and cognition. Treatments, including Trauma-Focused Cognitive Behavioural Therapy, have been shown to be efficacious, but high attrition rates point to the need for complementary methods that boost client retention and treatment efficacy.

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The Spherical Tokamak for Energy Production (STEP) programme is a world-leading fusion power plant programme that has embedded a cost conscience in its design from the early phases. This firmly addresses the attitude of cost complacency of which many major infrastructure projects have historically been accused. While a detailed and highly accurate whole life cycle cost analysis is not possible, or even valuable, during the conceptual design stage, this early design phase is still the most critical programme phase where a focus on costs can drive longer term reductions and impact whole life cycle costs at the high level.

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Background: A patient's subjective response to topical nasal decongestant is often used to screen for turbinate reduction surgery suitability. However, this anecdotal strategy has not been objectively and quantitatively evaluated.

Methods: Prospective, longitudinal, and single-blinded cohort study employing computational fluid dynamic modeling based on computed tomography scans at baseline, 30 min postoxymetazoline, and 2 months postsurgery on 11 patients with chronic turbinate hypertrophy.

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The advent of reversible deactivation radical polymerization (RDRP) revolutionized polymer chemistry and paved the way for accessing synthetic polymers with controlled sequences based on vinylic monomers. An inherent limitation of vinylic polymers stems from their all-carbon backbone, which limits both function and degradability. Herein, we report a synthetic strategy utilizing radical ring-opening polymerization (rROP) of complementary photoreactive cyclic monomers in combination with RDRP to embed photoresponsive functionality into desired blocks of polyvinyl polymers.

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Article Synopsis
  • - This study addresses the challenges of accurately segmenting airway trees in the context of diagnosing and characterizing chronic respiratory diseases, emphasizing the limitations of existing traditional methods requiring manual adjustments due to inconsistent segmentation results.
  • - It introduces a novel deep learning approach called Interpolation-Split, which enhances segmentation performance by improving data quality through interpolation and image splitting, while also being efficient in terms of computational resource usage.
  • - The results show that this new method significantly outperforms previous models in segmentation accuracy, achieving high dice similarity coefficients while requiring less GPU memory, making it more accessible for various computational environments.
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Inclusive research combines the expertise of academically trained researchers with the lived experience of individuals with disabilities to render results that are more accessible, accountable, and meaningful to the disability community. In this case study, adults with intellectual and developmental disabilities (IDD) contributed as co-researchers to a series of studies on mental health of adults with intellectual disability. The research model, specific engagement strategies, and lessons learned are shared.

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Here we introduce amphiphilic star polymers as versatile protein mimics capable of approximating the activity of certain native proteins. Our study focuses on designing a synthetic polymer capable of replicating the biological activity of TRAIL, a promising anticancer protein that shows very poor circulation half-life. Successful protein mimicry requires precise control over the presentation of receptor-binding peptides from the periphery of the polymer scaffold while maintaining enough flexibility for protein-peptide binding.

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Optically induced intersite spin transfer (OISTR) promises manipulation of spin systems within the ultimate time limit of laser excitation. Following its prediction, signatures of ultrafast spin transfer between oppositely aligned spin sublattices have been observed in magnetic alloys and multilayers. However, it is known neither from theory nor from experiment whether the band structure immediately follows the ultrafast change in spin polarization or whether the exchange split bands remain rigid.

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Intensity modulators are fundamental components for integrated photonics. From near-infrared (NIR) to visible spectral ranges, they find applications in optical communication and quantum technologies. In particular, they are required for the control and manipulation of atomic systems such as atomic clocks and quantum computers.

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Article Synopsis
  • The study aims to create standardized methodologies and processes for vaccine appraisal in the EU to improve decision-making in health technology assessment (HTA).
  • Researchers identified significant differences in vaccine evaluation practices across EU member states through literature reviews and expert consultations, leading to the development of three guiding principles.
  • The principles emphasize the need for better terminology, inclusive appraisal processes, and improved real-world data collection to support consistent and timely access to vaccines in the EU.
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Objectives: The Centers for Disease Control and Prevention (CDC) needs leaders at all levels who can address technical and adaptive challenges in a changing public health landscape. We assessed the feasibility of implementing an enterprise-wide leadership development model.

Methods: In June 2023, we launched a pilot program, Learn and Lead, for nonsupervisory staff in early and mid-career levels.

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