[Clinical significance of the changes of serum interleukin-18 and tumor necrosis factor-alpha levels in children with infectious mononucleosis].

Aim: To study the dynamic changes of levels of serum interleukin-18 (IL-18) and tumor necrosis factor-alpha (TNF-alpha) in children with infectious mononucleosis (IM).

Methods: 72 patients with IM were analyzed for the expression of TNF-alpha and IL-18 by RIA and ELISA, respectively in acute phase, convalescent phase, (the first month, the third month, the sixth month), and the control group.

Results: The levels of serum TNF-alpha and IL-18 in patients with IM were significantly higher than that in control (P < 0.

Novel phosphoramidates with porphine and nitrogenous drug: one-pot synthesis and orientation to cancer cells.

One-pot synthesis of novel phosphoramidates with porphine and nitrogenous drug was accomplished. In the absence of light, MTT test showed that they killed the BEL-7402 liver cancer cells effectively in vitro. The cell viability studied on normal liver and cancer cells showed that porphine phosphoramidates selectively kill the cancer cells, which was in sharp contrast with the non-porphine containing compound 4-formylphenyl N,N-bis(2-chloroethyl)-phosphoramidate.

Porphyrins containing nitric oxide donors: Synthesis and cancer cell-oriented NO release.

Four novel porphyrins containing nitric oxide (NO) donors were synthesized, and the structures of all the products were characterized by IR, UV-vis, (1)H NMR, and elementary analysis. Interestingly, these new compounds not only were able to release NO, but also showed cancer cell-oriented accumulation. Higher accumulation of these new porphyrins containing NO donors in BEL-7402 liver cancer cells than in L-02 liver normal cells was corroborated by UV-vis spectroscopy.