Publications by authors named "Chaoyun Gao"
Article Synopsis
- - The VII secretion system is crucial for mycobacterium to release proteins that enhance its virulence, with EsxA/B and EsxW/V being key vaccine targets, while the lesser-studied EsxO/P is thought to boost Th1 immune responses.
- - The research highlights Rv2347c, an ESAT-like protein, which disrupts phagosome maturation by blocking the early marker RAB5, facilitating mycobacterium survival and activating the STING/TBK1 pathway that promotes IFNβ production and inhibits autophagy.
- - Rv2347c not only aids in mycobacterial survival by evading immune responses but also activates pro-inflammatory pathways, indicating its potential
has evolved a highly specialized system to snatch essential nutrients from its host, among which host-derived cholesterol has been established as one main carbon source for to survive within granulomas. The uptake, catabolism, and utilization of cholesterol are important for to sustain within the host largely via remodeling of the bacterial cell walls. However, the regulatory mechanism of cholesterol uptake and its impact on bacterium fate within infected hosts remain elusive.
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