Effect of different cold acclimation methods on the exercise capacity of mice in low-temperature environments.

Objective: This study aimed to evaluate the effects of different cold acclimation strategies on exercise performance in male mice exposed to low-temperature environments.

Methods: Male mice were subjected to five distinct acclimation regimens over 8 weeks: immersion at 10 °C (10 °CI) or 20 °C (20 °CI), swimming at 10 °C (10 °CS), 20 °C (20 °CS), or 34 °C (34 °CS). During the first 2 weeks, the acclimation time progressively decreased from 30 min to 3 min per day, and the water temperatures were lowered from 34 °C to the target levels, followed by 6 weeks of consistent exposure.

Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.

The impact of housing temperature on exercise-induced metabolic adaptations is not well understood, despite extensive research on the benefits of exercise for metabolic health. The aim of this study was to elucidate how housing temperatures influence the molecular responses and metabolic benefits of exercise in mice. Male C57BL/6N mice were housed at either room temperature (RT, 21°C) or in a thermoneutral environment (TN, 29°C) and subjected to either a 6-week or acute exercise regimen.

The effects of exercise on microRNA expression profiling in adipose tissue macrophages of mice.

Background: Exercise is recognized for its broad health benefits, influencing various physiological processes, including the behavior of adipose tissue macrophages (ATMs). While existing studies mainly associate ATM activity with obesity and metabolic syndrome, our study explores the impact of aerobic exercise on ATM microRNA expression profiling in a non-obese context, highlighting its general health-promoting mechanisms.

Methods: Sixty male C57BL/6 mice were randomly assigned to either a sedentary (S) or an exercise (E) group.

Bidirectional regulation mechanism of TRPM2 channel: role in oxidative stress, inflammation and ischemia-reperfusion injury.

Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that exhibits Ca permeability. The TRPM2 channel is expressed in various tissues and cells and can be activated by multiple factors, including endogenous ligands, Ca, reactive oxygen species (ROS) and temperature. This article reviews the multiple roles of the TRPM2 channel in physiological and pathological processes, particularly on oxidative stress, inflammation and ischemia-reperfusion (I/R) injury.

Effects of mild hyperbaric oxygen therapy on timing sequence recovery of muscle fatigue in c u male athletes.

Objectives: This study aimed to investigate the timing sequence recovery effects of single and repeated Mild Hyperbaric Oxygen Therapy (MHOT) on muscle fatigue induced by cycling exercise through a comprehensive set of parameters.

Methods: This study employed a controlled crossover design involving 12 Chinese secondary national-level male athletes. Each participant completed two identical trials over six days.

Better Life's Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007-2010 data.

Objective: To investigate the relationship between Life's Essential 8 (LE8) and Phenotypic Age Acceleration (PhenoAgeAccel) in United States adults and to explore the impact of LE8 on phenotypic biological aging, thereby providing references for public health policies and health education.

Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2010, this cross-sectional study analyzed 7,339 adults aged 20 and above. Comprehensive assessments of LE8, PhenoAgeAccel, and research covariates were achieved through the integration of Demographics Data, Dietary Data, Laboratory Data, and Questionnaire Data derived from NHANES.

Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans.

Objectives: In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging.

Methods: Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.

Water Intake and Handgrip Strength in US Adults: A Cross-Sectional Study Based on NHANES 2011-2014 Data.

This study aimed to examine the relationship between daily total intake of water (DTIW) and handgrip strength (HGS) among US adults and to explore the impact of water intake on muscle function and health, providing a reference for public health policies and health education. Using the data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, a cross-sectional survey design was adopted to analyze 5427 adults (48.37% female and 51.

Effects of high-/low-temperature and high-altitude hypoxic environments on gut microbiota of sports people: A retrospective analysis.

As an invisible "endocrine organ", gut microbiota is widely involved in the regulation of nervous system, endocrine system, circulatory system, and digestive system. It is also closely related to host health and the occurrence of many chronic diseases. Relevant literature shows that high temperature, low temperature, and high-altitude hypoxia may have negative effects on commensal microorganisms.

The efficacy of vericiguat for heart failure: A meta-analysis of randomized controlled trials.

Background: The efficacy of vericiguat was elusive for heart failure. This meta-analysis aimed to explore the efficacy of vericiguat for heart failure.

Methods: PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases have been searched through October 2022 and we included randomized controlled trials reporting the effect of vericiguat versus placebo in patients with heart failure.

Network meta-analysis of intravitreal conbercept as an adjuvant to vitrectomy for proliferative diabetic retinopathy.

Purpose: Intravitreal Conbercept (IVC) has been shown to be effective in treating proliferative diabetic retinopathy (PDR) as an adjuvant in pars plana vitrectomy (PPV); however, the best timing of IVC injection remains unknown. This network meta-analysis (NMA) sought to ascertain the comparative efficacy of different timings of IVC injection as an adjuvant to PPV on PDR.

Methods: A comprehensive literature search was conducted in PubMed, EMBASE, and the Cochrane Library to identify relevant studies published before August 11, 2022.

Reductive damage induced autophagy inhibition for tumor therapy.

Unlabelled: Numerous therapeutic anti-tumor strategies have been developed in recent decades. However, their therapeutic efficacy is reduced by the intrinsic protective autophagy of tumors. Autophagy plays a key role in tumorigenesis and tumor treatment, in which the overproduction of reactive oxygen species (ROS) is recognized as the direct cause of protective autophagy.

Hydration monitoring and rehydration guidance system for athletes based on urine color's L*a*b* parameters.

Maintaining proper hydration is essential for athletes to sustain optimal performance and preserve their physical health. Existing studies have confirmed that urine color is one of the effective indicators for the subjective evaluation of athletes' hydration through the urine color chart. However, the use of urine color charts to evaluate hydration is easily affected by the test environment, urine container and subjective feeling.

Cryotherapy on Subjective Sleep Quality, Muscle, and Inflammatory Response in Chinese Middle- and Long-Distance Runners After Muscle Damage.

Qu, C, Wu, Z, Xu, M, Lorenzo, S, Dong, Y, Wang, Z, Qin, F, and Zhao, J. Cryotherapy on subjective sleep quality, muscle, and inflammatory response in Chinese middle- and long-distance runners after muscle damage. J Strength Cond Res 36(10): 2883-2890, 2022-The purpose of this investigation was to explore the effects of cold-water immersion (CWI), contrast-water therapy (CWT), and whole-body cryotherapy (CRY) on subjective sleep quality, muscle damage markers, and inflammatory markers in middle- and long-distance runners after muscle damage.

Validation of urine colour L*a*b* for assessing hydration amongst athletes.

Objectives: Existing studies have confirmed that urine colour through a urine colour chart is one of the effective indicators for assessing hydration. In recent years, the L*a*b* colour space has been widely used in the objective quantitative analysis of colour. The L*, a* and b* values represent the luminance change from black to white, the chromaticity change from green to red and the chromaticity change from blue to yellow, respectively.

Amelioration of Ambient Particulate Matter (PM)-Induced Lung Injury in Rats by Aerobic Exercise Training.

Ambient particulate matter (PM), as an inflammation-inducing factor, increases the prevalence of lung injury. The aim of this study was to examine the protective effect and mechanism of aerobic exercise on PM exposure-induced lung injury. Forty Wistar rats were randomly divided into four groups: sedentary+PM exposure, exercise+PM exposure, sedentary, and exercise groups.

Aerobic exercise ameliorates particulate matter-induced lung injury in aging rats.

Particulate matter 2.5 (PM) is an inflammatory-inducing factor that is considered to be related to many adverse respiratory problems, especially in the elderly. This study aimed to examine whether pre-exercise training could prevent pulmonary injury induced by urban PM in aging rats and investigate its relationship with inflammatory pathways.

Maximum oxygen consumption and quantification of exercise intensity in untrained male Wistar rats.

This study aimed to explore a valid test protocol for measuring VO in healthy untrained male Wistar rats of different ages and quantifying the exercise intensity (%VO) of running under different treadmill grades and speeds. The test protocols and %VO will provide a reference for the design of exercise intensity. We tested male Wistar rats aged 4 weeks, 10 weeks, 10 months and 16 months old with three test protocols (Procedure 1 [P1], 2 [P2] and 3 [P3]) for each age group to quantify VO.

Cryotherapy Models and Timing-Sequence Recovery of Exercise-Induced Muscle Damage in Middle- and Long-Distance Runners.

Context: Among sports-recovery methods, cold-water immersion (CWI), contrast-water therapy (CWT), and whole-body cryotherapy (WBC) have been applied widely to enhance recovery after strenuous exercise. However, the different timing effects in exercise-induced muscle damage (EIMD) after these recovery protocols remain unknown.

Objective: To compare the effects of CWI, CWT, and WBC on the timing-sequence recovery of EIMD through different indicator responses.

Photolyase-Like Catalytic Behavior of CeO.

Nanomaterials with intrinsic enzyme-like characteristics exhibit their great potentials as alternatives to natural enzymes. Among various enzymes, the finding of substitutes of DNA photolyases, a family of photoenzymes for repairing the ultraviolet (UV)-induced DNA damage by forming cyclobutane pyrimidine dimers (CPDs) between two adjacent thymines in a DNA strand, is still unsuccessful. CPDs raise significant health concerns in various skin diseases.

Catalytically Selective Chemotherapy from Tumor-Metabolic Generated Lactic Acid.

Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments (TMEs). Inspired by its high intratumoral level (5-20 µmol g ), a novel treatment paradigm via the cascade release of H O and ·OH from the LA generated by tumor metabolism is developed for catalytic and pH-dependent selective tumor chemotherapy. By utilizing the acidity and overexpression of LA within the TME, the constructed lactate oxidase (LOD)-immobilized Ce-benzenetricarboxylic acid (Ce-BTC) metal organic framework enables the intratumoral generation of ·OH via a cascade reaction: 1) the in situ catalytic release of H O from LA by LOD, and 2) the catalytic production of ·OH from H O by Ce-BTC with peroxidase-like activity.

MicroRNA-137 regulates hypoxia-induced retinal ganglion cell apoptosis through Notch1.

The apoptosis of retinal ganglion cells (RGCs) is a hallmark of several optic neuropathies. MicroRNAs (miRNAs) are recently identified regulators of various biological processes. However, the role of miRNAs in regulating RGC apoptosis remains largely unknown.

Gene Expression Profiling of the Optic Nerve Head of Patients with Primary Open-Angle Glaucoma.

. The pressure-induced axonal injury of the vulnerable ONH has led many researchers to view glaucoma from the perspective of the genetic basis of the angle of the ONH. However, genetic studies on POAG from this perspective are limited.

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults.

To assess the effects of resistance training on circulating irisin concentration in older male adults, and to investigate the association between resistance training induced alteration of irisin and body fat. Seventeen older adults (mean age is 62.1 years old) were randomized into old control group (male, = 7), and old training group (male, = 10).