Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
October 2018
Objective: To explore the molecular mechanism of Yishen Huoxue prescription in delaying the development of renal fibrosis by regulating the microRNA-126/vascular endothelial growth factor-Notch (miR-126/VEGF-Notch) signaling pathway.
Methods: Ninety male Sprague-Dawley (SD) rats were randomly divided into sham operation group (sham group), unilateral ureteral obstruction (UUO) model group, losartan group (50 mg×kg×d) and high, medium and low doses Yishen Huoxue prescription group (25.2, 12.