Occurrence, source apportionment and ecological risk assessment of thirty antibiotics in farmland system.

Antibiotics are widely used in medical care, livestock production, and aquaculture. However, antibiotic pollution has attracted increasing global concerns due to their ecological risks after entering into environmental ecosystem via animal excretion, effulent from industrial and domestic sewage treatment facilities. In this study, 30 antibiotics were investigated in soils and irrigation rivers using ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometer.

Occurrence, Distribution and Ecological Risk of Bisphenol Analogues in the Surface Water from a Water Diversion Project in Nanjing, China.

Due to the widespread use of bisphenol analogues (BPs) as alternatives to bisphenol A (BPA), considerable attention for health risk has been shown in aquatic ecosystems. The occurrence and distribution of six BPs were researched in a soluble phase (<10 μm), colloidal phase (10 μm to 1 µm), and suspended particulate matter (SPM >1 µm) in a water diversion project of Nanjing, China. Except for bisphenol Z, all BPs were detected in two or three phases, where the total concentrations of detected BPs were 161-613 ng/L, 5.

[Distribution and Environmental Risk of Pharmaceutically Active Compounds in the Traditionally Aqueous Phase of Effluent-receiving Rivers].

Colloid media are not only an important "sink" for pollutants in the aquatic environment, but also a crucial regulating unit for the biogeochemical cycle of pollutants. In this study, the distribution and environmental risk levels of ten typical pharmaceutically active compounds (PhACs) in the water phase of effluent-receiving rivers were investigated using cross-flow ultrafiltration, solid-phase extraction, and liquid chromatography-tandem mass spectrometry as the pretreatment and analysis methods. The results showed that the total concentrations of the ten PhACs in the dissolved phase and colloidal phase ranged from 27.

Properties of Hemoglobin Decolorized with a Histidine-Specific Protease.

This study investigated the application of Aspergilloglutamic peptidase (AGP) on porcine hemoglobin decolorization. AGP from fungus Aspergillus niger is identified to possess a high preference towards the histidine residues. As histidine residues in hemoglobin are known to coordinate the heme group within the globin molecule, we therefore hypothesized that incubating hemoglobin with a histidine-specific protease would efficiently separate the non-heme peptides from the heme-enriched peptides with a minimum degree of hydrolysis.

Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins.

The Parkinson's disease (PD) associated gene PINK1 encodes a protein kinase that mediates the phosphorylation of multiple proteins involved in mitochondrial homeostasis. The broader downstream signaling events mediated by PINK1 kinase activity have not been well documented. We combine quantitative phosphoproteomic strategies with siRNA mediated PINK1 knock down in mammalian cells to identify alterations of phosphorylation events downstream of PINK1.

Diversity of (dihydro) hydroxycinnamic acid conjugates in Colombian potato tubers.

In potato tuber, caffeic acid (the predominant hydroxycinnamic acid (HCA)), its conjugates (HCAcs; i.e. chlorogenic acid (ChA), crypto-ChA, and neo-ChA), and anthocyanin-linked HCAs have been extensively described in the literature.