G6PD inhibits ferroptosis in hepatocellular carcinoma by targeting cytochrome P450 oxidoreductase.

Ferroptosis is an important cell necrosis and has been a focus in cancer related research.Increcsing studies have focused on the phenotype and function of ferroptosis in tumorigenesis, but the underlying mechanism remains poorly understood. Here, we used bioinformatics approaches to identify differentially expressed genes associated with HCC and ferroptosis.

A new contrast-to-noise ratio for image quality characterization of a coded-aperture γ camera.

The gamma-ray imaging technique was developed and is widely used in several nuclear engineering fields. Specifically, compared with the traditional point-by-point radiation detector, the coded-aperture gamma camera has advantages of a wide field of view, high angular resolution, and high efficiency. Several methods for characterizing image quality, including the figure of merit (FOM) method and the contrast-to-noise ratio (CNR) method, were assessed and developed.

Design of an Am-Be neuron source experimental platform at Sichuan University.

Am-Be neutron sources are widely used in nuclear laboratories. It is important to design adequate shielding for Am-Be neutron sources, in order to protect experimenters from being irradiated by neutrons and their associated γ-rays. When designing shielding, it is also much desired for the source assembly to provide sufficient neutron moderation, and furnish access channels for both thermal and fast neutrons directly from the source.

Development of an isocentric rotating chair positioner to treat patients of head and neck cancer at upright seated position with multiple nonplanar fields in a fixed carbon-ion beamline.

Purpose: An isocentric rotating chair for a positioner was developed as a nongantry solution to provide multiple nonplanar radiation fields with a maximum tilt of 20 for treating head and neck cancer patients at an upright seated position in a fixed carbon-ion beamline.

Methods: The preclinical validation of the chair was present for this study funded by a grant through the Shanghai Proton and Heavy Ion Center (SPHIC) in Shanghai, China. The chair was installed in SPHIC.

Generation of a human control PBMC derived iPS cell line TUSMi001-A from a healthy male donor of Han Chinese genetic background.

A 59-year old healthy man of Han Chinese genetic background donated his peripheral blood mononuclear cells (PBMC). The non-integrating episomal vector system was used to reprogram his PBMCs with the human OSKM (Oct4, Sox2, Kl4 and c-Myc) transcription factors. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry for pluripotency markers and by the ability of the iPSCs to differentiate spontaneously into 3 germ layers in vitro.

Design, development and evaluation of a resistor-based multiplexing circuit for a 20×20 SiPM array.

One technical challenge in developing a large-size scintillator detector with multiple Silicon Photomultiplier (SiPM) arrays is to read out a large number of detector output channels. To achieve this, different signal multiplexing circuits have been studied and applied with different performances and cost-effective tradeoffs. Resistor-based multiplexing circuits exhibit simplicity and signal integrity, but also present the disadvantage of timing shift among different channels.

Natural and artificial radionuclide measurements and radioactivity assessment of soil samples in eastern Sichuan province (China).

The activity concentrations of natural and artificial radionuclides were measured in the eastern region of Sichuan province (China). One hundred and ninety-three soil samples from this region were collected and analysed by high-purity germanium gamma spectrometry. The measured results show that the average radioactivity concentrations of (226)Ra, (232)Th, (40)K and (137)Cs in the soil samples are 26, 49, 440 and 6 Bq kg(-1), respectively.

Protective effects of inosine on mice subjected to lethal total-body ionizing irradiation.

Mammals can barely survive total-body ionizing irradiation greater than 10 Gy. To date, there are few drugs available for radioprotective therapy under such circumstances. Inosine, a natural derivative of adenosine, has been known to provide powerful protection for many kinds of cells and tissues against various insults both in vitro and in vivo.