Vitamin D protects intrauterine growth restriction induced by cooking oil fume derived fine particulate matters.

Background: Cooking oil fume (COF) is an important source of indoor air pollution which severely affects human health, and sufficient vitamin D (VitD) is necessary for maternal and child health. However, the effects of cooking oil fume-derived PM (COF-PM) on birth outcomes and whether VitD could protect from adverse effects caused by COFs-PM are still unclear.

Methods: Twenty-four pregnant rats were divided into 4 groups and treated with various treatments: normal feeding, COFs-PM intratracheal instillation, VitD intragastric administration, and COFs-PM and VitD co-treatment, respectively.

Effects of long-term exposure to air pollution on the incidence of type 2 diabetes mellitus: a meta-analysis of cohort studies.

This meta-analysis aimed to comprehensively assess the effects of long-term air pollution exposure on the risk of type 2 diabetes mellitus (T2DM). Studies were selected from three electronic databases. Random- or fixed-effect model was used to obtain the pooled hazard ratios (HRs) and corresponding 95% confidential intervals (CIs).

Associations of ambient PM and O with cardiovascular mortality: a time-series study in Hefei, China.

China is among the countries with the worst air quality throughout the world. As PM was not included in the national air quality monitoring network before January 2013 in China, no study has investigated the associations of ambient PM and O with cardiovascular mortality in Hefei, China. In this time-series analysis, Poisson regression in generalized additive model was adopted to assess the associations between the air pollutants and cardiovascular mortality during the 2013-2015 in Hefei, China.

Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells.

In China, cooking oil fume derived fine particulate matter (COF-derived PM) is a principal source of indoor air pollution. Here, we investigated cytotoxicity of COF-derived PM, as well as the roles of VEGF, VEGFR2, MEK1/2, ERK1/2, and mTOR cascade in the inhibitory effects of COF-derived PM, on angiogenesis in human umbilical vein endothelial cells (HUVECs). After exposure to COF-derived PM, cell viability and tube formation, as well as protein and mRNA levels of VEGF, VEGFR2, MEK1/2, ERK1/2, and mTOR in HUVECs were measured.

The effects of cooking oil fumes-derived PM on blood vessel formation through ROS-mediated NLRP3 inflammasome pathway in human umbilical vein endothelial cells.

Background: Cooking oil fumes (COFs), a main pollutant in kitchen air, is a major risk to human health. In our previous research, exposure to COFs-derived PM could cause umbilical vascular endothelial dysfunction, leading to decreased fetal weight. Here, to test the role of ROS-mediated NLRP3 inflammasome pathway in blood vessel formation of human umbilical vein endothelial cells (HUVECs) caused by COFs-derived PM, the cells were exposed to COFs-derived PM at different concentrations with and without N-acetyl-L-cysteine (NAC).

The short-term effects of air pollution on respiratory diseases and lung cancer mortality in Hefei: A time-series analysis.

Accumulating evidence has shown the effects of air pollution on respiratory disease and lung cancer mortality, but the evidence is still inconclusive to date. We conducted a time-series analysis, which included 10388 subjects, to assess the short-term effects of air pollution on respiratory disease and lung cancer mortality in Hefei, China, from 2009 to 2015. The mean concentrations of pollutants (PM, NO and SO) were 106.