Hierarchical lncRNA regulatory network in early-onset severe preeclampsia.

Background: Recent studies have shown that several long non-coding RNAs (lncRNAs) in the placenta are associated with preeclampsia (PE). However, the extent to which lncRNAs may contribute to the pathological progression of PE is unclear.

Results: Here, we report a hierarchical regulatory network involved in early-onset severe PE (EOSPE).

Comparison of the EPDS and PHQ-9 in the assessment of depression among pregnant women: Similarities and differences.

Background: Perinatal depression has attracted increasing attention. However, a detailed investigation of the network structure of depression is still lacking. We aim to examine the similarities and differences between the Edinburgh Postnatal Depression Scale (EPDS) and Patient Health Questionnaire (PHQ-9) from a network perspective.

Antenatal depression is associated with perceived stress, family relations, educational and professional status among women in South of China: a multicenter cross-sectional survey.

Background: Antenatal depression is a commonly seen mental health concern for women. This study introduced a multicenter cross-sectional survey with a large sample to provide new insights into pregnant women's depression, its socio-demographic and obstetric characteristics correlates, and its perceived stress among Chinese pregnant women.

Methods: This study conducted an observational survey according to the STROBE checklist.

A longitudinal study of perinatal depression and the risk role of cognitive fusion and perceived stress on postpartum depression.

Aims And Objectives: To explore fluctuations in perinatal depression based on physiological, psychological and interpersonal dimensions to analyse risk factors across three time points: in the third trimester and at weeks 1 and 6 postpartum.

Background: Pregnant women experience depression at multiple time points and require screening. Studies have shown protective and negative factors related to postpartum depression.

Iron parameters in pregnant women with beta-thalassaemia minor combined with iron deficiency anaemia compared to pregnant women with iron deficiency anaemia alone demonstrate the safety of iron supplementation in beta-thalassaemia minor during pregnancy.

In patients with beta-thalassaemia intermedia or major, hepcidin induces iron overload by continuously promoting iron absorption. There have been no studies in pregnant women with beta-thalassaemia minor combined with iron deficiency anaemia (IDA), examining whether hepcidin is inhibited by GDF15, as may occur in patients with beta-thalassaemia intermedia or major, or whether the iron metabolism characteristics and the effect of iron supplementation are consistent with simple IDA in pregnancy. We compared and analysed routine blood parameters, iron metabolism parameters, the GDF15 levels, and the hepcidin levels among four groups, namely the beta-thalassaemia (β) + IDA, β, IDA, and normal groups.

Distinct placental molecular processes associated with early-onset and late-onset preeclampsia.

Patients with preeclampsia display a spectrum of onset time and severity of clinical presentation, yet the underlying molecular bases for the early-onset and late-onset clinical subtypes are not known. Although several transcriptome studies have been done on placentae from PE patients, only a small number of differentially expressed genes have been identified due to very small sample sizes and no distinguishing of clinical subtypes. We carried out RNA-seq on 65 high-quality placenta samples, including 33 from 30 patients and 32 from 30 control subjects, to search for dysregulated genes and the molecular network and pathways they are involved in.

TNF-related apoptosis-inducing ligand (TRAIL) promotes trophoblast cell invasion via miR-146a-EGFR/CXCR4 axis: A novel mechanism for preeclampsia?

Introduction: Preeclampsia (PE) is associated with failure of uterovascular transformation due to impaired trophoblast invasion. Previously, TNF-related apoptosis-inducing ligand (TRAIL) has been controversially reported to correlate with PE, but whether it regulates trophoblast invasion yet to be defined.

Methods: We treated HTR8/SVneo cells with sTRAIL at concentrations of 0.

[Effect of mindfulness meditation training on anxiety, depression and sleep quality in perimenopausal women].

Objective: To explore the effect of mindfulness meditation training for improving anxiety, depression and sleep disorders in perimenopausal women.

Methods: Intervention by menopause meditation training was delivered in 121 perimenopausal women with anxiety, depression or sleep disorders in Baiyun District, Guangzhou. Before and after the intervention, the Self-rating Anxiety Scale, Self-rating Depression Scale and Pittsburg Sleep Quality Index were used for assessment of changes in the conditions of the women.

Adsorption behaviours and mechanisms of heavy metal ions' impact on municipal waste composts with different degree of maturity.

Composting may change the adsorption characteristics and mechanisms of organic materials due to their differences in organic chemical functional groups and surface structures. The adsorption properties of heavy metals onto the municipal solid waste compost (MSW-C) and its secondary fermentation form (MSW-SC) were comparatively investigated in single, binary and multiple solutions by batch experiments. In the single-metal system, the maximum adsorption capacities of Cu, Zn, Cd and Ni onto MSW-SC were 29.

[Prenatal diagnosis of single umbilical artery: implications for chromosomal abnormalities and neonatal outcome].

Objective: To investigate the implications of a prenatal diagnosis of single umbilical artery (SUA) for chromosomal abnormalities and neonatal outcomes.

Methods: From January, 2008 to June, 2012, color Doppler ultrasound identified 44 fetuses with SUA. Prenatal diagnoses with amniocentesis or umbilical blood sampling were subsequently ordered for routine chromosome karyotyping and the newborns were followed up for assessing the neonatal outcomes.

[Hysterectomy after cardiopulmonary resuscitation in patients with obstetric hemorrhagic shock].

Objective: To explore the indication of hysterectomy after successful resuscitation of cardiac arrest due to obstetric hemorrhagic shock.

Methods: A retrospective analysis was conducted in 13 patients with cardiac arrest due to obstetric hemorrhagic shock in 7 hospitals of Guangzhou, including 12 patients undergoing hysterectomy and 1 undergoing uterine artery embolization.

Results: s After successful cardiopulmonary resuscitation, only 4 of the 13 patients undergoing hysterectomy or uterine artery embolization for continuing uterus hemorrhage survived.