Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players.

Background: Inhalation of hydrogen gas (H) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.

Methods: A randomized, placebo-controlled, double-blind, crossover trial was conducted with professional male rugby players for 3 weeks.

Effects of Quartz Sand on the Electromagnetic Wave Absorption of Cementitious Materials.

The roles of dielectric materials in adjusting the electromagnetic wave (EMW) absorption performance of an EMW absorber are as crucial as the EMW absorbents. The commonly used cement-based materials, such as mortar, are typical composites of multiple dielectric materials, such as quartz sand and air in the pores. This study investigates the EMW-absorption performances within the frequency range of 2 GHz to 18 GHz of cement paste and mortar samples with different sand-to-cement ratios (S/C), water-to-cement ratios (W/C), and thicknesses.

Combating tumor PARP inhibitor resistance: Combination treatments, nanotechnology, and other potential strategies.

PARP (poly (ADP-ribose) polymerase) inhibitors (PARPi) have demonstrated significant potential in cancer treatment, particularly in tumors with breast cancer susceptibility gene (BRCA) mutations and other DNA repair deficiencies. However, the development of resistance to PARPi has become a major challenge in their clinical application. The emergence of drug resistance leads to reduced efficacy of the PARPi over time, impacting long-term treatment outcomes and survival rates.

Chitosan-gelatin composite hydrogel antibacterial film for food packaging.

Antibacterial hydrogel film can serve as food packaging materials to prevent bacteria growth and spread, thereby extending shelf life and improve food safety. In this study, an efficient antibacterial hydrogel film (CLG) was prepared with chitosan, lysine, and gelatin. The light transmission of the CLG hydrogel film was over 80 % in the visible region, facilitating the observation of chicken breast storage conditions.

IRIS, a randomised, double-blind, placebo-controlled trial of interleukin-6 receptor inhibition undergoing endovascular treatment in acute anterior circulation ischaemic stroke: study rationale and design.

Rationale: Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke (AIS). Preclinical research indicates that tocilizumab, an interleukin-6 receptor antagonist, can attenuate ischaemia-reperfusion damage by exerting anti-inflammatory and neuroprotective effects.

Aim: To determine tocilizumab's efficacy and safety when combined with endovascular thrombectomy (EVT) in patients with acute anterior circulation large vessel occlusion (LVO).

Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER-TRPV1 Ion Channels in Multimodal Killing of Glioblastoma.

Glioblastoma (GBM) with highly immunosuppressive tumor microenvironment is a significant factor contributing to its treatment resistance and low survival rate. The activation of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which is overexpressed on the endoplasmic reticulum (ER) of GBM cells, governs the control of multi-organelle stress pathway branches to inhibit GBM expansion. Precise modulation of ER-TRPV1 is considered an effective strategy for inhibition of GBM.

Carboxymethylcellulose-based aggregation-induced emission antibacterial material for multifunctional applications.

Polysaccharides are ubiquitous in nature, typically harmless, and highly compatible with various tissues in biomedical contexts. These properties make them attractive for use in multifunctional materials. In this study, the aggregation-induced emission (AIE) antibacterial material (PLOCMC) was successfully synthesized by carboxymethylcellulose (CMC) and ε-Poly-Lysine (ε-PL).

A novel energy efficient QoS secure routing algorithm for WSNs.

Quality of Service (QoS) routing protocol is a hot topic in the research field of wireless sensor networks (WSNs). However, the task of identifying an optimal path that simultaneously meets multiple QoS constraints is acknowledged as an NP-hard problem, with its complexity intensifying in proportion to the network's nodal count. Therefore, a novel heuristic multi-objective trust routing method, the Levy Chaos Adaptive Snake Optimization-based Multi-Trust Routing Method (LCASO-MTRM), is proposed, aiming to enhance link bandwidth while simultaneously reducing latency, packet loss, and energy consumption.

Integrated PacBio SMRT and Illumina sequencing uncovers transcriptional and physiological responses to drought stress in whole-plant .

Introduction: Bobr., a prominent xerophytic shrub, exhibits remarkable adaptability to harsh environment and plays a significant part in preventing desertification in northwest China owing to its exceptional drought and salinity tolerance.

Methods: To investigate the drought-resistant mechanism underlying , we treated 8-week-old seedlings with polyethylene glycol (PEG)-6000 (20%, m/m) to induce drought stress.

From light into shadow: comparative plastomes in Petrocosmea and implications for low light adaptation.

Background: Plastids originated from an ancient endosymbiotic event and evolved into the photosynthetic organelles in plant cells. They absorb light energy and carbon dioxide, converting them into chemical energy and oxygen, which are crucial for plant development and adaptation. However, little is known about the plastid genome to light adaptation.

Development and validation of an explainable machine learning model for predicting multidimensional frailty in hospitalized patients with cirrhosis.

We sought to develop and validate a machine learning (ML) model for predicting multidimensional frailty based on clinical and laboratory data. Moreover, an explainable ML model utilizing SHapley Additive exPlanations (SHAP) was constructed. This study enrolled 622 patients hospitalized due to decompensating episodes at a tertiary hospital.

Copper Sulfide based Photocatalysts, Electrocatalysts and Photoelectrocatalysts: Innovations in Structural Modulation and Application.

Copper sulfides (CuS, 1 ≤ x ≤ 2) are notable for their unique photoelectric properties and potential applications, particularly in photo/electrocatalysis. These materials are valued for their tunable band gap, near-infrared optical characteristics, and plasmonic resonance effects. However, challenges such as low catalytic activity and limited stability impede their practical applications.

Mapping and visualization of global research progress on deubiquitinases in ovarian cancer: a bibliometric analysis.

Background: Ovarian cancer is a highly aggressive malignancy with limited therapeutic options and a poor prognosis. Deubiquitinating enzymes (DUBs) have emerged as critical regulators of protein ubiquitination and proteasomal degradation, influencing various cellular processes relevant to cancer pathogenesis. In this study, the research progress between ovarian cancer and DUBs was mapped and visualized using bibliometrics, and the expression patterns and biological roles of DUBs in ovarian cancer were summarized.

Chitosan-based hydrogel dressings with antibacterial and antioxidant for wound healing.

Bacterial infection and free radical oxidative stress at the wound site could easily cause cascade inflammation and hinder the healing process of the wound. In this study, chitosan-cysteine-gallic acid (CCG) hydrogel with antibacterial and antioxidant properties was synthesized by chitosan (CS), cysteine (Cys), and gallic acid (GA) for a preliminary evaluation of its therapeutic efficacy in a mouse model of full-layer skin defect. In vitro analysis showed that the CCG hydrogel had good antibacterial activity and blood compatibility.

Unlocking Lattice Oxygen on Selenide-Derived NiCoOOH for Amine Electrooxidation and Efficient Hydrogen Production.

In pursuit of advancing the electrooxidation of amines, which is typically encumbered by the inertness of C(sp)-H/N(sp)-H bonds, our study introduces a high-performance electrocatalyst that significantly enhances the production efficiency of vital chemicals and fuels. We propose a novel electrocatalytic strategy employing a uniquely designed (NiCo)Se-R electrocatalyst, which is activated through Se-O exchange and electron orbital spin manipulation. This catalyst efficiently generates M species, thus enabling the activation of lattice oxygen and streamlining the electrooxidation of amines.

Intersubject Dynamic Conditional Correlation: A Novel Method to Track the Framewise Network Implication during Naturalistic Stimuli.

Naturalistic stimuli have become increasingly popular in modern cognitive neuroscience. These stimuli have high ecological validity due to their rich and multilayered features. However, their complexity also presents methodological challenges for uncovering neural network reconfiguration.

A Zero-Shot Learning Approach for Blockage Detection and Identification Based on the Stacking Ensemble Model.

A data-driven approach to defect identification requires many labeled samples for model training. Yet new defects tend to appear during data acquisition cycles, which can lead to a lack of labeled samples of these new defects. Aiming at solving this problem, we proposed a zero-shot pipeline blockage detection and identification method based on stacking ensemble learning.

A sex-oriented analysis concerning skeletal muscle quantity and quality and associations to quality of life in hospitalized patients with cirrhosis.

Background: There is a paucity of data regarding sex-oriented analyses of connection between muscle quantity and quality and health-related quality of life (HRQoL), taking into account the pathophysiological differences of sarcopenia/myosteatosis in males versus females. We sought to investigate the associations between skeletal muscle index (SMI)-defined sarcopenia and intramuscular adipose tissue content (IMAC)-defined myosteatosis and EuroQol-5D (EQ-5D)-defined HRQoL in patients with decompensated cirrhosis concerning sex disparities.

Methods: Totally, 382 patients were enrolled.

Spatial Confinement of Lithium Borohydride in Bimetallic CoNi-Doped Hollow Carbon Frameworks for Stable Hydrogen Storage.

While lithium borohydride is one of the most promising hydrogen storage materials due to its ultrahigh hydrogen storage density, high thermodynamic stability, kinetic barriers, and poor reversibility, it is far from being used in practical applications. Herein, we prepare a cubic hollow carbon dodecahedron uniformly modified with a bimetallic CoNi alloy (CoNi/NC) for preserving the stable catalytic effect of CoNi alloys toward reversible hydrogen storage. It is theoretically confirmed that bimetallic CoNi alloys effectively weaken the B-H bonds of LiBH by extending their average length to 1.

Click Chemistry in Detecting Protein Modification.

Click chemistry, also known as "link chemistry," is an important molecular connection method that can achieve simple and efficient connections between specific small molecular groups at the molecular level. Click chemistry offers several advantages, including high efficiency, good selectivity, mild conditions, and few side reactions. These features make it a valuable tool for in-depth analysis of various protein posttranslational modifications (PTMs) caused by changes in cell metabolism during viral infection.